Recombination property of the HIV-1 gp120 gene

International Reviews of Immunology
Jelena PrljicVeljko Veljkovic

Abstract

Using a chimeric primer consisting of the nucleotide sequence derived from the HIV-1 envelope gene coding for the second conserved region of gp120, and the highly conserved sequence derived from the human immunoglobulin gene coding for the VHIII domain, it has been identified in sera of AIDS patients HIV-1 field isolates carrying the complete and active Chi recombination hot spot (GCTGGTGG). The recombination between the HIV-1 gene coding for the central portion of gp120 and the bacterial gene coding for the clp protease was also demonstrated in vivo. These results point out serious concern that vectored AIDS vaccine candidates carrying the HIV-1 env gene on viral and bacterial vectors could become the source of potentially new infectious diseases rather than an effective instrument for AIDS prevention.

References

Mar 11, 1990·Nucleic Acids Research·A M KrowczynskaT G Krontiris
Nov 1, 1990·Journal of Clinical Microbiology·D De WitM Sogin
Mar 1, 1995·Trends in Microbiology·E J JohnsonA A Gottlieb
Jul 9, 1996·Proceedings of the National Academy of Sciences of the United States of America·H AokiO Hino

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Citations

Jan 1, 2008·Vaccine·Veljko VeljkovicMae-Wan Ho
Jun 19, 2008·The Journal of General Virology·Francisco M Codoñer, Santiago F Elena

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