Recombined humanized endostatin (Endostar) intravenous infusion in the treatment of refractory nasopharyngeal carcinoma: Three case reports

Medicine
Chen ChenYun-Fei Xia

Abstract

Refractory nasopharyngeal carcinoma is challenging to treat and at present there is no standard treatment or any good choice. Although the three patients in our case reports had already underwent multiple treatments before, they still suffered from disease recurrence of nasopharyngeal carcinoma. They were diagnosed as refractory nasopharyngeal carcinoma. A continuous infusion of Endostar, an antiangiogenic agent, combined with chemotherapy and radiation therapy was given to treat the patients. Patients showed complete or partial response to the combined therapy as evidenced by regression of tumors and decrease in plasma Epstein-Barr virus (EBV) DNA load. Continuous infusions of Endostar in combination with chemotherapy and/or radiation therapy showed promising efficacy and safety. The combination therapy indicates a new approach to treat refractory nasopharyngeal carcinoma.

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Methods Mentioned

BETA
biopsy
xenograft

Clinical Trials Mentioned

NCT02590133

Software Mentioned

Endostar

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