Recommendation for measuring and reporting chloride by ISEs in undiluted serum, plasma or blood

Clinical Chemistry and Laboratory Medicine : CCLM
Mohammed C Ben RayanaInternational Federation of Clinical Chemistry and Laboratory Medicine (IFCC)


The proposed recommendation for measuring and reporting chloride in undiluted plasma or blood by ion-selective electrodes (ISEs) will provide results that are identical to chloride concentrations measured by coulometry for standardized normal plasma or blood samples. It is applicable to all current ISEs dedicated to chloride measurement in undiluted samples that meet the requirements. However, in samples with reduced water concentration, results by coulometry are lower than by ion-selective electrode due to volume displacement. The quantity measured by this standardized ISE procedure is called the ionized chloride concentration. It may be clinically more relevant than the chloride concentration as determined by coulometry, photometry or by ISE after dilution of the sample.


Jul 15, 1987·Clinica Chimica Acta; International Journal of Clinical Chemistry·G M de JongC H Gips
Jun 1, 1970·Clinica Chimica Acta; International Journal of Clinical Chemistry·A H Maas
Jan 1, 1984·Scandinavian Journal of Clinical and Laboratory Investigation. Supplementum·O P Hansen
Nov 16, 2001·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·K TohdaY Umezawa


Jul 11, 2012·International Journal of Nephrology·Tetsuya MakiishiKunihiko Hirose
Dec 14, 2007·The Tohoku Journal of Experimental Medicine·Kazuhiko KotaniNaoki Sakane
Oct 14, 2009·Clinical Biochemistry·Raffick A R BowenAlan T Remaley
May 24, 2015·Analytica Chimica Acta·Grzegorz LisakJohan Bobacka
Sep 10, 2015·Clinical Chemistry and Laboratory Medicine : CCLM·Nienke GeertsVolkher Scharnhorst

Related Concepts

Chloride Ion Level
Indicator Dilution Techniques
Fresh Frozen Plasma
Ion-Selective Electrodes

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