Recommendation of long-term and systemic management according to the risk factors in rectal NETs patients

Scientific Reports
Motohiro KojimaAtsushi Ochiai

Abstract

Rectal neuroendocrine tumors (NETs) are often found as small lesions, which can be treated by endoscopic resection. However, high risk cases with lymph node (LN) metastasis are indication of radical surgery. Furthermore, rectal NETs are often associated with late recurrences and/or multiple cancer development. Therefore, proper surgical indication and patients' management are required. We investigated the clinicopathological features of 79 rectal NET cases in order to elucidate risk factors for synchronous LN metastasis, recurrence, and multiple cancers. Recently, we reported that in pancreatic NET patients, a loss of heterozygosity (LOH) in PHLDA3 was associated with poorer prognosis, and that LOH of both PHLDA3 and MEN1 was frequently observed. Therefore, PHLDA3 and MEN1 LOH were also assessed in rectal NET patients for their association with clinicopathological features. Of the 79 patients, LN metastases were found in 12.7%, recurrences in 3.8%, and multiple cancers in 30.4% of the subjects. PHLDA3 and MEN1 LOH were found in 60.0% and 66.7% of the subjects, respectively. Lymphatic invasion and WHO classification 2010 were found to be independent risks for LN metastasis. There were three cases of recurrence, all of which occu...Continue Reading

References

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Citations

Jun 12, 2020·International Journal of Molecular Sciences·Yu Chen, Rieko Ohki
Jul 22, 2019·Best Practice & Research. Clinical Endocrinology & Metabolism·Louis de MestierPhilippe Ruszniewski

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Methods Mentioned

BETA
PCR
surgical
dissection
surgical resection

Software Mentioned

Genotyper
GeneScan
Minitab

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