Recommendations for further revisions to improve the International Agency for Research on Cancer (IARC) Monograph program.

Regulatory Toxicology and Pharmacology : RTP
Julie E GoodmanNeeraja K Erraguntla

Abstract

In 2019, the International Agency for Research on Cancer (IARC) "Preamble to the IARC Monographs" expanded guidance regarding the scientific approaches that should be employed in its monographs. These amendments to the monograph development process are an improvement but still fall short in several areas. While the revised Preamble lays out broad methods and approaches to evaluate scientific evidence, there is a lack of specificity with regard to how IARC Working Groups will conduct consistent evaluations in a standardized, objective, and transparent manner; document systematic review and evidence integration actions, and substantiate how these actions and decisions inform the ultimate classifications. Furthermore, no guidance is provided to ensure Working Groups consistently incorporate mechanistic evidence in a robust manner using a defined approach in the context of 21st century knowledge of modes of action. Nor are the conclusions of the working groups subjected to outside, independent scientific peer review. Continued improvements and modernization of the procedures for evaluating, presenting, and communicating study quality, and in the methods used to conduct and peer-review evidence-based decision making will benefit the...Continue Reading

Related Concepts

Related Feeds

Cancer Incidence & Mortality

Cancer has emerged as a global concern due to its increase in incidence and mortality. Efforts are underway to evaluate and develop action plans to reduce the global burden of cancer. Currently, lung cancer, breast cancer and prostate cancer are the leading causes of cancer mortality. Here is the latest research on cancer incidence and mortality.

Related Papers

Giornale italiano di medicina del lavoro ed ergonomia
Benedetto Terracini
Giornale italiano di medicina del lavoro ed ergonomia
Roberta PirastuPietro Comba
International Journal of Occupational and Environmental Health
Paul Kleihues
Lancet
Bernard W StewartTimo Kauppinen
© 2021 Meta ULC. All rights reserved