PMID: 15379300Sep 24, 2004Paper

Recommendations for the care of women with epilepsy

Cleveland Clinic Journal of Medicine
Patricia E PenovichVasiliki V Economou

Abstract

The clinical care of women with epilepsy entails special considerations over the life span. Endogenous depression is more prevalent in persons with epilepsy than in the general population and may be unrecognized. Seizure frequency may be influenced by hormonal fluctuations, as reflected by catamenial patterns in up to 25% of women and by changes at menopause. Fertility is lower in women with epilepsy. These women should be evaluated for anovulatory cycles and particularly for polycystic ovary syndrome, with its attendant health risks. It is important to provide folate supplementation during the childbearing years and to evaluate bone health throughout life, providing calcium and vitamin D supplementation when indicated. Particular consideration is indicated before conception and during pregnancy to minimize both potential teratogenicity secondary to antiepileptic drugs (AEDs) and the risks that seizures pose to fetus and mother. At delivery, vitamin K is indicated. Some infants may need to be monitored for AED withdrawal, while others may require a perinatal team if malformations are identified in utero. Breast-feeding is possible, with sedation rarely being a problem. Recognition, evaluation, and management of these issues wil...Continue Reading

Citations

Jun 20, 2012·Current Treatment Options in Neurology·Kaarkuzhali Babu Krishnamurthy
Jan 26, 2008·The Neurologist·María Isabel ForcadasJavier Salas Puig
Mar 11, 2008·MCN. the American Journal of Maternal Child Nursing·Jennifer B Rousseau
Aug 7, 2013·Seminars in Perinatology·Laura A Hart, Baha M Sibai
Dec 26, 2006·Women's Health Issues : Official Publication of the Jacobs Institute of Women's Health·Kathleen C WatsonKevin C Cain
Jun 13, 2006·Epilepsy & Behavior : E&B·Ian ThorneycroftJames Simon
Dec 26, 2007·Seizure : the Journal of the British Epilepsy Association·Eylert Brodtkorb, Arne Reimers
Oct 1, 2009·The Journal of Pediatric Pharmacology and Therapeutics : JPPT : the Official Journal of PPAG·Sunila E O'Connor, Mary L Zupanc

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