Recommendations for use of everolimus after heart transplantation: results from a Latin-American Consensus Meeting

Transplantation Proceedings
E A BocchiS V Perrone

Abstract

Despite improvements during the last decades, heart transplantation remains associated with several medical complications, which limit clinical outcomes: acute rejection with hemodynamic compromise, cytomegalovirus (CMV) infections, allograft vasculopathy, chronic renal failure, and neoplasias. Everolimus, a proliferation signal inhibitor, represents a new option for adjunctive immunosuppressive therapy. Everolimus displays better efficacy in de novo heart transplant patients than azathioprine for prophylaxis of biopsy-proven acute rejection episodes of at least ISHLT grade 3A (P < .001), of allograft vasculopathy (P < .01), and of CMV infections (P < .01). These findings suggest that everolimus potentially play an important role as part of immunosuppressive therapy in heart transplant recipients. Heart transplant investigators from Latin America produced recommendations for everolimus use in daily practice based on available data and their own experience.

References

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Citations

Jul 10, 2008·Expert Opinion on Drug Metabolism & Toxicology·Ana I Sánchez-Fructuoso
Jul 14, 2010·Transplantation Reviews·Nicolás ManitoJavier Segovia
Sep 25, 2007·Transplantation Proceedings·J MoroA Salvador
Mar 23, 2010·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Einar GudeArne K Andreassen

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