Recommendations To Address the Difficulties Encountered When Determining Linezolid Resistance from Whole-Genome Sequencing Data

Antimicrobial Agents and Chemotherapy
Alicia G BeukersSebastiaan J van Hal

Abstract

Mutations associated with linezolid resistance within the V domain of 23S rRNA are annotated using an Escherichia coli numbering system. The 23S rRNA gene varies in length, nucleotide sequence, and copy number among bacterial species. Consequently, this numbering system is not intuitive and can lead to confusion when mutation sites are being located using whole-genome sequencing data. Using the mutation G2576T as an example, we demonstrate the difficulties associated with using the E. coli numbering system.

References

Sep 18, 2002·Antimicrobial Agents and Chemotherapy·S H MarshallL B Rice
Sep 25, 2003·Antimicrobial Agents and Chemotherapy·Michael LobritzLouis B Rice
Jan 24, 2008·Antimicrobial Agents and Chemotherapy·Silke BesierThomas A Wichelhaus
Dec 7, 2011·Antimicrobial Agents and Chemotherapy·Katherine S Long, Birte Vester

❮ Previous
Next ❯

Citations

Sep 11, 2019·The Journal of Antimicrobial Chemotherapy·Kate E WardenburgGautam Dantas
Apr 1, 2021·Genome Medicine·Sebastiaan J van HalUNKNOWN Enterococcal Group
Jun 8, 2021·Frontiers in Cellular and Infection Microbiology·Alicia G BeukersSebastiaan J van Hal

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antimicrobial Resistance (ASM)

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Antimicrobial Resistance

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

CRISPR Screens in Drug Resistance

CRISPR-Cas system enables the editing of genes to create or correct mutations. This feed focuses on the application of CRISPR-Cas system in high-throughput genome-wide screens to identify genes that may confer drug resistance.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.