PMID: 9188108Jan 1, 1997Paper

Recommended use of morphine in neonates, infants and children based on a literature review: Part 2--Clinical use

Paediatric Anaesthesia
T KartM Rasmussen

Abstract

The indication for morphine use is primarily pain, but also a combined analgesic and sedative effect may be the rationale behind morphine administration. Paediatric morphine regimens have been reported for children with postoperative pain, pain related to cancer, sickle cell crisis pain, burns and AIDS. No dose response curve for morphine in neonates, infants or children has been established, and different levels for the minimum effective plasma concentration have been estimated. The side effects observed in neonates, infants, and children are similar to those observed in adults, and neonates do not seem to be more susceptible to respiratory depression than older children. Despite shortcomings in the knowledge of the pharmacodynamics of morphine, it can be considered safe to administer morphine to neonates, infants or children. Initial regimens has been calculated from the pharmacokinetic parameters of morphine, but treatment must be adjusted according to analgesic effect and incidence of side effects.

References

Sep 1, 1979·Clinical Pharmacology and Therapeutics·B DahlströmL Paalzow
Jan 1, 1992·Developmental Pharmacology and Therapeutics·P D WalsonM A Torch
Oct 1, 1992·Clinical Pharmacology and Therapeutics·E L MaunukselaR E Bullingham
Mar 21, 1992·BMJ : British Medical Journal·G K Gourlay, R A Boas
May 1, 1992·Journal of Pain and Symptom Management·T R Vetter
Mar 1, 1992·Clinical Pharmacology and Therapeutics·P C ChayJ S Walker
Feb 1, 1992·Journal of Pain and Symptom Management·R S Litman, B S Shapiro
Oct 1, 1991·Burns : Journal of the International Society for Burn Injuries·P B GaukrogerR B Davey
Oct 1, 1991·Research in Nursing & Health·M D TeslerS M Paul
Sep 1, 1991·Journal of Clinical Anesthesia·S Serlin
Jan 1, 1991·Anesthesia and Analgesia·R D Valley, A G Bailey
Nov 1, 1990·Anaesthesia·M J Mowbray, P B Gaukroger
Dec 1, 1990·Anaesthesia·S C LawrieN S Morton
Dec 1, 1990·British Journal of Clinical Pharmacology·I CederholmA Rane
Mar 1, 1990·Journal of Adolescent Health Care : Official Publication of the Society for Adolescent Medicine·D C Tyler
Apr 1, 1990·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·D K RaschM A Gurkowski
Jan 1, 1990·Clinical Pediatrics·J D TobiasM Solca
Jul 1, 1989·Anesthesiology·E J KraneL E Jacobson
Aug 1, 1989·Anaesthesia and Intensive Care·P B GaukrogerJ H van der Walt
Aug 1, 1988·Clinical Pharmacology and Therapeutics·K T OlkkolaP H Rosenberg
May 1, 1988·Spine·B Dalens, A Tanguy
Apr 1, 1987·The Australian and New Zealand Journal of Surgery·S W Beasley, J Tibballs
Jan 1, 1988·British Journal of Anaesthesia·E L MaunukselaK T Olkkola
Jan 1, 1988·Journal of Pain and Symptom Management·N L SchechterS M Katz
Mar 1, 1988·Journal of Pediatric Surgery·B M RodgersB M Newman
Jul 1, 1986·Anaesthesia·R J BrayJ A Seviour
Feb 1, 1984·British Journal of Anaesthesia·S E JonesG Hall-Davies
Oct 1, 1984·Critical Care Medicine·A M LynnD C Tyler
Aug 1, 1984·Anesthesiology·L A ShapiroS Hoffman
Aug 1, 1984·Mayo Clinic Proceedings·J A GlenskiB Kaufman

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Citations

Mar 21, 2002·Paediatric Anaesthesia·Brian J Anderson, George H Meakin
Nov 16, 2004·Palliative Medicine·Sebastiano Mercadante
May 30, 2009·Pharmacotherapy·Gail D Anderson, Anne M Lynn
Jul 14, 2010·Pediatric Surgery International·B MessererA Sandner-Kiesling
Jul 12, 2011·Internal and Emergency Medicine·Ersilia LucenteforteAlessandro Mugelli
May 9, 2014·Paediatric Anaesthesia·Thanaporn Jitpakdee, Sahatsa Mandee
Jan 21, 2014·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Nicholas WestGillian Lauder
Jul 28, 2016·Paediatric Anaesthesia·Miriam I EmonsJoachim Erlenwein
Mar 21, 2018·Frontiers in Pharmacology·Frédérique RodieuxCaroline F Samer
Mar 21, 2020·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Anita K PatelMurray M Pollack
Aug 21, 2001·Clinical Pharmacokinetics·J Lötsch, G Geisslinger
Oct 3, 2006·Current Opinion in Anaesthesiology·G Allen Finley
Jun 27, 2007·Journal of Perinatology : Official Journal of the California Perinatal Association·M F El SayedA M Moore
Oct 11, 2014·The Cochrane Database of Systematic Reviews·Adrian MurphyNandini Kandamany
Oct 31, 2014·Journal of Perinatology : Official Journal of the California Perinatal Association·M S BrownL M Thornton
Oct 17, 2014·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Vidya ChidambaranMark J Meyer
Oct 1, 2014·Paediatric Anaesthesia·Michelle A Fortier, Zeev N Kain
May 27, 2016·Journal of Clinical Pharmacology·Adam FrymoyerKrisa P Van Meurs
Oct 28, 2016·Expert Review of Clinical Pharmacology·Manuel A BaarslagDick Tibboel
Feb 15, 2019·PloS One·Laurent M A FaviéUNKNOWN PharmaCool study group
Jan 17, 2019·Clinical Pharmacology and Therapeutics·Frédérique RodieuxCaroline F Samer
Jan 12, 2010·Paediatric Anaesthesia·Michael TremlettAndrew Wolf
Feb 6, 2014·Clinical Pharmacokinetics·Elke H J KrekelsCatherijne A J Knibbe
Sep 11, 2019·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Pooja Shah, Anita Siu
Sep 1, 2007·The Cleft Palate-craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association·S Fenlon, N Somerville
Nov 26, 2003·Journal of Pain & Palliative Care Pharmacotherapy·Ralph A Lugo, Steven E Kern
Mar 20, 2013·Canadian Pharmacists Journal : CPJ = Revue Des Pharmaciens Du Canada : RPC·Cecile WongFiona Campbell
Nov 6, 2009·Paediatric Anaesthesia·Neil S Morton, Agata Errera
Nov 4, 2017·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Michelle L CzarneckiSteven J Weisman
Oct 4, 2014·Paediatric Anaesthesia·Stefan Lundeberg
Jan 11, 2014·Paediatric Drugs·Christopher BrasherSouhayl Dahmani
Apr 15, 2014·Korean journal of anesthesiology·Ji Yeon Lee, Youn Yi Jo
Sep 29, 1998·Annales Françaises D'anesthèsie Et De Rèanimation·J X Mazoit
Sep 29, 1999·Pharmacology & Therapeutics·A R Lloyd-Thomas
Jun 3, 2021·Children·Costanza TognonPiergiorgio Gamba
Jul 13, 2005·Pediatric Clinics of North America·Christine Greco, Charles Berde
Mar 15, 2002·Anesthesiology Clinics of North America·Mark W Farrar, Jerrold Lerman
Oct 17, 2002·Clinics in Perinatology·Anna Taddio
Aug 26, 2009·Anesthesiology Clinics·F Wickham Kraemer, John B Rose
Aug 30, 2008·British Journal of Anaesthesia·K J S AnandUNKNOWN NEOPAIN Trial Investigators Group
Apr 12, 2012·Pediatrics·Lauren E KellyGideon Koren

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