Reconciling conflicting clinical studies of antioxidant supplementation as HIV therapy: a mathematical approach.

BMC Public Health
Rolina D van Gaalen, Lindi M Wahl

Abstract

Small, highly reactive molecules called reactive oxygen species (ROS) play a crucial role in cell signalling and infection control. However, high levels of ROS can cause significant damage to cell structure and function. Studies have shown that infection with the human immunodeficiency virus (HIV) results in increased ROS concentrations, which can in turn lead to faster progression of HIV infection, and cause CD4+ T-cell apoptosis. To counteract these effects, clinical studies have explored the possibility of raising antioxidant levels, with mixed results. In this paper, a mathematical model is used to explore this potential therapy, both analytically and numerically. For the numerical work, we use clinical data from both HIV-negative and HIV-positive injection drug users (IDUs) to estimate model parameters; these groups have lower baseline concentrations of antioxidants than non-IDU controls. Our model suggests that increases in CD4+ T cell concentrations can result from moderate levels of daily antioxidant supplementation, while excessive supplementation has the potential to cause periods of immunosuppression. We discuss implications for HIV therapy in IDUs and other populations which may have low baseline concentrations of a...Continue Reading

References

Jan 1, 1992·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·D S GoodinR S Chequer
Mar 1, 1993·Mathematical Biosciences·A S PerelsonR De Boer
Jun 1, 1994·Chemico-biological Interactions·J M Gutteridge
Apr 16, 1996·Proceedings of the National Academy of Sciences of the United States of America·M LevineL R Cantilena
Jan 1, 1996·Free Radical Biology & Medicine·K B Schwarz
Jul 1, 1995·Chemistry & Biology·A U Khan, T Wilson
Feb 3, 1998·Cellular and Molecular Life Sciences : CMLS·N Israël, M A Gougerot-Pocidalo
Jul 2, 1998·Epidemiology·W W Fawzi, D J Hunter
May 20, 2000·Proceedings. Biological Sciences·L M Wahl, M A Nowak
Dec 29, 2000·Journal of Acquired Immune Deficiency Syndromes : JAIDS·A M Tang, E Smit
Feb 13, 2001·The Journal of Clinical Investigation·J HiscottP Génin
Jul 13, 2002·Journal of Cellular Physiology·Jennifer L Martindale, Nikki J Holbrook
Oct 22, 2002·Mathematical Biosciences·P van den Driessche, James Watmough
Nov 16, 2002·Proceedings of the National Academy of Sciences of the United States of America·Ruy M RibeiroAlan S Perelson
Nov 26, 2002·Nature Immunology·Michael Reth
Feb 20, 2003·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Lizette GilOlga Sonia León
Feb 10, 2004·Mathematical Biosciences·Michele Di MascioAlan S Perelson
Feb 26, 2004·The Journal of Emergency Medicine·Kenneth S Hickey, Timothy C Evans
Feb 27, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Wafaie FawziDeborah Anderson
Jun 9, 2004·Free Radical Biology & Medicine·David A Hildeman
Dec 1, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Helena C F OliveiraAníbal E Vercesi
Jan 11, 2005·Archives of Biochemistry and Biophysics·Konstantina Karyotou, Robert P Donaldson
Jan 27, 2005·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Charles B StephensenCraig M Wilson
Jan 29, 2005·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Stephen M CarlinMichael Roth
Mar 30, 2005·The Journal of Nutrition·Wafaie FawziDavid J Hunter
May 19, 2005·Clinical Chemistry and Laboratory Medicine : CCLM·Odilon de Souza JúniorCelso Spada
Apr 8, 2006·The American Journal of Clinical Nutrition·Charles B StephensenCraig M Wilson
May 26, 2006·Biochemical Pharmacology·Geoffrey GloireJacques Piette
Feb 8, 2007·The American Journal of Clinical Nutrition·Paul K DrainWafaie W Fawzi

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Citations

Jan 1, 2009·BMC Public Health·Robert J Smith, Richard Gordon
Sep 19, 2017·Molecular BioSystems·Aurelia A WilliamsDebra Meyer

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