Reconciling persistent and dynamic hypotheses of working memory coding in prefrontal cortex.

Nature Communications
Sean E CavanaghSteven W Kennerley

Abstract

Competing accounts propose that working memory (WM) is subserved either by persistent activity in single neurons or by dynamic (time-varying) activity across a neural population. Here, we compare these hypotheses across four regions of prefrontal cortex (PFC) in an oculomotor-delayed-response task, where an intervening cue indicated the reward available for a correct saccade. WM representations were strongest in ventrolateral PFC neurons with higher intrinsic temporal stability (time-constant). At the population-level, although a stable mnemonic state was reached during the delay, this tuning geometry was reversed relative to cue-period selectivity, and was disrupted by the reward cue. Single-neuron analysis revealed many neurons switched to coding reward, rather than maintaining task-relevant spatial selectivity until saccade. These results imply WM is fulfilled by dynamic, population-level activity within high time-constant neurons. Rather than persistent activity supporting stable mnemonic representations that bridge subsequent salient stimuli, PFC neurons may stabilise a dynamic population-level process supporting WM.

References

Mar 1, 1976·Journal of Comparative and Physiological Psychology·R H Bauer, J M Fuster
Feb 1, 1989·Journal of Neurophysiology·S FunahashiP S Goldman-Rakic
Aug 13, 1971·Science·J M Fuster, G E Alexander
Sep 1, 1984·The Journal of Comparative Neurology·M Petrides, D N Pandya
Mar 1, 1995·Neuron·P S Goldman-Rakic
Aug 1, 1996·Journal of Neurophysiology·C Constantinidis, M A Steinmetz
Jul 19, 2000·Journal of Neurophysiology·W F AsaadE K Miller
Dec 18, 2001·Human Brain Mapping·Thomas E Nichols, Andrew P Holmes
May 2, 2002·The European Journal of Neuroscience·Gregor Rainer, Earl K Miller
Feb 13, 2003·Annals of the New York Academy of Sciences·David C Van Essen
Jan 27, 2004·Proceedings of the National Academy of Sciences of the United States of America·X-J WangP S Goldman-Rakic
Jul 21, 2004·Journal of Chemical Neuroanatomy·G PaxinosP M Sexton
Oct 29, 2004·PLoS Biology·Mikhail A LebedevSteven P Wise
Jun 7, 2005·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Michael Petrides
Oct 7, 2005·Cerebral Cortex·C AmiezE Procyk
Apr 13, 2007·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Paul Cisek
Mar 15, 2008·Science·Gianluigi MongilloMisha Tsodyks
Jun 20, 2008·Journal of Neurophysiology·Ethan M MeyersTomaso Poggio
Aug 30, 2008·Journal of Cognitive Neuroscience·Steven W KennerleyJonathan D Wallis
Feb 27, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Satoshi TsujimotoSteven P Wise
Mar 3, 2009·Neuron·Mark S Goldman
Mar 13, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Steven W Kennerley, Jonathan D Wallis
Sep 25, 2009·Journal of Neurophysiology·Steven W Kennerley, Jonathan D Wallis
Jul 16, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Omri BarakRanulfo Romo
Nov 26, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Melissa R Warden, Earl K Miller
Feb 15, 2011·Nature Neuroscience·Alberto BernacchiaXiao-Jing Wang
Apr 5, 2011·Annual Review of Neuroscience·Camillo Padoa-Schioppa
Oct 23, 2012·Current Biology : CB·Shaul Druckmann, Dmitri B Chklovskii
Dec 18, 2012·Nature Neuroscience·Mototaka Suzuki, Jacqueline Gottlieb
Apr 9, 2013·Neuron·Mark G StokesJohn Duncan
May 21, 2013·Nature·Mattia RigottiStefano Fusi
Nov 10, 2013·Nature·Valerio ManteWilliam T Newsome

❮ Previous
Next ❯

Citations

Aug 14, 2019·Annals of the New York Academy of Sciences·Jan Kamiński, Ueli Rutishauser
Mar 3, 2020·PLoS Biology·Michael J WolffMark G Stokes
Nov 7, 2019·Cerebral Cortex·Mikiko KadohisaJohn Duncan
Nov 5, 2019·Nature Communications·Aishwarya ParthasarathyCamilo Libedinsky
Jan 31, 2020·Proceedings of the National Academy of Sciences of the United States of America·Kathrin MüschChristopher J Honey
Sep 30, 2020·ELife·Sean Edward CavanaghSteven Wayne Kennerley
May 16, 2019·Nature Reviews. Neuroscience·Kartik K Sreenivasan, Mark D'Esposito
Aug 26, 2020·Proceedings of the National Academy of Sciences of the United States of America·Mehran SpitmaanAlireza Soltani
Oct 23, 2019·Proceedings of the National Academy of Sciences of the United States of America·Robert KimTerrence J Sejnowski
Dec 13, 2019·Nature Communications·Byung-Il OhMin-Suk Kang
Nov 17, 2020·Biological Psychiatry·Bo XingWen-Jun Gao
Jan 12, 2021·Frontiers in Neuroinformatics·Zitong Lu, Yixuan Ku
Jan 6, 2021·Trends in Cognitive Sciences·Elizabeth S LorencJarrod A Lewis-Peacock
Jan 8, 2021·Frontiers in Neural Circuits·Sean E CavanaghSteven W Kennerley
Apr 18, 2021·The European Journal of Neuroscience·Laurence T Hunt
Jun 2, 2021·PLoS Computational Biology·Lucas RudeltViola Priesemann
May 25, 2021·Current Opinion in Behavioral Sciences·Alireza SoltaniDaeyeol Lee
Aug 10, 2021·Frontiers in Neural Circuits·Clayton E Curtis, Thomas C Sprague
Aug 21, 2021·Neuron·R Becket Ebitz, Benjamin Y Hayden
Sep 16, 2021·PLoS Computational Biology·Elham Ghazizadeh, ShiNung Ching

❮ Previous
Next ❯

Methods Mentioned

BETA
PCA

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Proceedings of the National Academy of Sciences of the United States of America
John D MurrayXiao-Jing Wang
The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Eelke SpaakMark G Stokes
The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Omri BarakRanulfo Romo
The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Puiu F Balan, V P Ferrera
© 2022 Meta ULC. All rights reserved