Reconsidering Aromatase for Breast Cancer Treatment: New Roles for an Old Target.

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Jessica CaciollaSilvia Gobbi

Abstract

The current therapeutic approach for the treatment of hormone dependent breast cancer includes interference with estrogen receptors via either selective modulators or estrogens deprivation, by preventing their biosynthesis with aromatase inhibitors. Severe side effects and acquired resistance are drawbacks of both drug classes, and the efforts to overcome these issues still allow for research in this field to be animated. This review reports on recent findings that have opened new avenues for reconsidering the role of aromatase enzymes (and estrogen receptors) leading to the possibility of looking at well-known targets in a new perspective.

References

Nov 26, 1998·The New England Journal of Medicine·C K Osborne
Oct 3, 2001·Physiological Reviews·S NilssonJ A Gustafsson
Dec 23, 2004·Endocrine-related Cancer·Alistair Ring, Mitch Dowsett
Apr 28, 2005·Clinical Journal of Oncology Nursing·Catherine Burke
Aug 19, 2006·Breast Disease·Joan S Lewis-Wambi, V Craig Jordan
Jun 23, 2007·The Journal of Steroid Biochemistry and Molecular Biology·Sampo KarkolaKristiina Wähälä
Jul 7, 2007·Physiological Reviews·Nina HeldringJan-Ake Gustafsson
Nov 2, 2007·Medical Oncology·Udayan Dutta, Kartikeya Pant
Oct 8, 2009·The Journal of Steroid Biochemistry and Molecular Biology·Debashis GhoshWalter Pangborn
Oct 13, 2009·Mini Reviews in Medicinal Chemistry·Tianlin WangHua Xiang
Jan 26, 2010·Expert Opinion on Drug Metabolism & Toxicology·Silvia Dellapasqua, Marco Colleoni
Sep 28, 2010·Journal of Oncology·Qamar J KhanPriyanka Sharma
Oct 7, 2010·Expert Opinion on Drug Safety·Catherine M Kelly, Aman U Buzdar
Nov 26, 2010·The Journal of Steroid Biochemistry and Molecular Biology·Muhammad AkhtarPeter Lee-Robichaud
Feb 22, 2011·The Journal of Steroid Biochemistry and Molecular Biology·Saranya ChumsriAngela Brodie
Mar 11, 2011·Breast Cancer Research and Treatment·Wenjie Jessie LuDavid A Flockhart
Sep 7, 2012·Journal of Medicinal Chemistry·Debashis GhoshHuw M L Davies
Sep 18, 2012·Archives of Biochemistry and Biophysics·Takashi IyanagiJung-Ja P Kim
Mar 19, 2013·Steroids·Carla L VarelaElisiário J Tavares-da-Silva
Apr 17, 2013·Biotechnology and Applied Biochemistry·Giovanna Di Nardo, Gianfranco Gilardi
Jul 23, 2013·Anti-cancer Agents in Medicinal Chemistry·Silvia GobbiAlessandra Bisi
May 3, 2014·Cancer Letters·Hamed Samavat, Mindy S Kurzer
Sep 23, 2014·Endocrinology·Chinaza EgbutaDebashis Ghosh
Sep 25, 2014·Journal of the American Chemical Society·Francis K Yoshimoto, F Peter Guengerich
Oct 30, 2014·Biochemia Medica·Peter VrtačnikJanja Marc
Aug 26, 2015·Best Practice & Research. Clinical Endocrinology & Metabolism·Min JiaJan-Åke Gustafsson
Aug 23, 2016·International Journal of Molecular Sciences·Milena Rondón-LagosPeter G Zaphiropoulos
Aug 27, 2016·Clinical Breast Cancer·Jennifer FogliettaStefania Gori
Dec 7, 2016·British Journal of Cancer·Stine DaldorffJürgen Geisler
Apr 9, 2017·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Toru Hanamura, Shin-Ichi Hayashi
Apr 20, 2017·The Journal of Physical Chemistry Letters·Alessandra MagistratoAndrea Cavalli
Oct 6, 2017·Advances in Anatomy, Embryology, and Cell Biology·Jolanta SaczkoJulita Kulbacka

❮ Previous
Next ❯

Citations

Mar 17, 2021·Molecular and Cellular Endocrinology·Rita Bernhardt, Jens Neunzig
Jun 3, 2021·International Journal of Molecular Sciences·Ersilia NigroLuigi Sapio
Jul 6, 2021·ChemMedChem·David K HeidaryEdith C Glazer
Aug 14, 2021·Frontiers in Endocrinology·Tara HyderAdam M Brufsky

❮ Previous
Next ❯

Methods Mentioned

BETA
X-ray

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Duodecim; lääketieteellinen aikakauskirja
O Ahokosk, E Salminen
JAMA : the Journal of the American Medical Association
Rowan T Chlebowski
© 2021 Meta ULC. All rights reserved