Reconsidering idiopathic CK-elevation

The International Journal of Neuroscience
Josef FinstererBettina Mittendorfer

Abstract

This study investigated the frequency of persisting, idiopathic creatine-kinase (CK)-elevation, how often the cause of idiopathic CK-elevation could be clarified, and the most frequent causes of idiopathic CK-elevation. Among 28 patients with previously idiopathic CK-elevation, CK remained elevated in 32%. The cause of idiopathic CK-elevation could be determined in 46%. Causes were mitochondriopathy (n = 5), seizure (n = 2), stroke (n = 2), myositis (n = 1), intramuscular-injection (n = 1), alcohol myopathy (n = 1), and pravastátin myopathy (n = 1). In 10 of these patients CK was normal at follow-up. CK-elevation remained idiopathic in 54%. Idiopathic CK-elevation should be comprehensively re-evaluated, even if CK is only slightly elevated or normal at follow-up.

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Citations

Jan 22, 2008·Clinics in Sports Medicine·Paola BrancaccioFrancesco Mario Limongelli
Apr 3, 2008·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Steven K Baker, Imtiaz A Samjoo
Mar 10, 2011·Journal of Strength and Conditioning Research·Magdalena WiacekIgor Z Zubrzycki
Nov 20, 2019·Journal of Clinical Neuromuscular Disease·Josef FinstererCarla A Scorza

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