PMID: 6165020Mar 1, 1981Paper

Reconstitution of Ir genes, Ia antigens, and mixed lymphocyte reaction determinants by gene complementation

Proceedings of the National Academy of Sciences of the United States of America
C G FathmanC S David

Abstract

By using clones of murine T cells reactive with alloantigens as well as soluble antigens, it has been possible to demonstrate that Ia antigens, Ir gene phenomena (defined as the ability of immune T cells to recognize antigen), and mixed lymphocyte reaction (MLR)-stimulating determinants encoded within the I-A subregion are different manifestations associated with same product. These studies utilized the I-Ab mutant mouse B6.C-H-2bm (bm12), whose defect in the normal expression of the cell surface products of the I-Ab subregion can be partially circumvented through trans-complementation by deriving hybrids between bm12 and mice expressing normal I-A subregion products. Such mice [e.g., (bm12 X B10.A)F1] express several serologically normal I-Ab products but have defects in certain I-A subregion gene products normally expressed on cells of H-2a X H-2b heterozygote mice that are used as restricting elements for antigen recognition by antigen-reactive T cell clones or recognized as alloantigens by alloreactive T cell clones. This defect in cell surface expression of certain normal I-Ab products on the mutant bm12 cells has allowed us to suggest that there exist trans-complementing products on H-2a X H-2b heterozygote mice consistin...Continue Reading

References

Jan 1, 1978·Immunological Reviews·B Benacerraf, R N Germain
Nov 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·C G Fathman, H Hengartner
Oct 1, 1978·The Journal of Experimental Medicine·P P JonesH O McDevitt
Dec 1, 1979·The Journal of Experimental Medicine·I F McKenzieH I Kohn
Nov 1, 1974·The Journal of Experimental Medicine·J A FrelingerD C Shreffler
Oct 1, 1980·The Journal of Experimental Medicine·E A LernerD B Murphy
Jul 1, 1980·Immunogenetics·I F McKenzieR W Melvold
Mar 1, 1980·The Journal of Experimental Medicine·W P LafuseC S David
May 29, 1980·Nature·T H HansenD H Sachs

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Citations

Jan 1, 1982·Immunogenetics·W P LafuseC S David
Jan 1, 1983·Immunogenetics·J P TingJ A Frelinger
Jan 1, 1984·Immunogenetics·D G SpinellaH C Passmore
Jan 1, 1987·Immunology Today·D Isenberg, Y Shoenfeld
Oct 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·C C LinT H Hansen
Jun 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·C E Hayes, D A Hullett
May 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·R N GermainJ Y Tou
Aug 1, 1982·The Journal of Experimental Medicine·H Y LeiC Waltenbaugh
Oct 1, 1982·The Journal of Experimental Medicine·B N BeckC G Fathman
Mar 1, 1983·The Journal of Experimental Medicine·G M Shearer, R B Levy
Oct 1, 1985·The Journal of Experimental Medicine·P M AllenL H Glimcher
Jan 1, 1990·The Journal of Experimental Medicine·W W KwokG T Nepom
Jan 1, 1987·Immunology Today·L H Glimcher, I J Griffith
Dec 1, 1982·Immunology Today·D F NixonJ A Frelinger
Feb 1, 1984·Australian and New Zealand Journal of Medicine·P A GatenbyA Basten
Jan 1, 1986·Microbiology and Immunology·M Kimoto, C G Fathman

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