Reconstruction and analysis of human liver-specific metabolic network based on CNHLPP data

Journal of Proteome Research
Jing ZhaoZhiwei Cao

Abstract

Liver is the largest internal organ in the body that takes central roles in metabolic homeostasis, detoxification of various substances, as well as in the synthesis and storage of nutrients. To fulfill these complex tasks, thousands of biochemical reactions are going on in liver to cope with a wide range of foods and environmental variations, which are densely interconnected into an intricate metabolic network. Here, the first human liver-specific metabolic network was reconstructed according to proteomics data from Chinese Human Liver Proteome Project (CNHLPP), and then investigated in the context of the genome-scale metabolic network of Homo sapiens. Topological analysis shows that this organ-specific metabolic network exhibits similar features as organism-specific networks, such as power-law degree distribution, small-world property, and bow-tie structure. Furthermore, the structure of liver network exhibits a modular organization where the modules are formed around precursors from primary metabolism or hub metabolites from derivative metabolism, respectively. Most of the modules are dominated by one major category of metabolisms, while enzymes within same modules have a tendency of being expressed concertedly at protein lev...Continue Reading

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Citations

Feb 3, 2016·Frontiers in Neuroscience·Haochen LiuXiaoquan Liu
Apr 10, 2013·Scientific Reports·Jing ZhaoPetter Holme
Sep 9, 2010·Molecular Systems Biology·Germán PlataDennis Vitkup
Aug 16, 2014·BioMed Research International·Yue-Dong GaoJingfei Huang
Dec 21, 2011·Molecular BioSystems·Tong HaoIgor Goryanin

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