Reconstruction of effective connectivity in the case of asymmetric phase distributions

Journal of Neuroscience Methods
Azamat YeldesbaySilvia Daun

Abstract

The interaction of different brain regions is supported by transient synchronization between neural oscillations at different frequencies. Different measures based on synchronization theory are used to assess the strength of the interactions from experimental data. One method of estimating the effective connectivity between brain regions, within the framework of the theory of weakly coupled phase oscillators, was implemented in Dynamic Causal Modelling (DCM) for phase coupling (Penny et al., 2009). However, the results of such an approach strongly depend on the observables used to reconstruct the equations (Kralemann et al., 2008). In particular, an asymmetric distribution of the observables could result in a false estimation of the effective connectivity between the network nodes. In this work we built a new modelling part into DCM for phase coupling, and extended it with a distortion function that accommodates departures from purely sinusoidal oscillations. By analysing numerically generated data sets with an asymmetric phase distribution, we demonstrated that the extended DCM for phase coupling with the additional modelling component, correctly estimates the coupling functions. The new method allows for different intrinsic f...Continue Reading

Citations

Oct 28, 2019·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·Tomislav StankovskiAneta Stefanovska

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