PMID: 15387966Sep 25, 2004Paper

Reconstruction of erectile reflex circuit by autologous vein graft combined with use of insulin-like growth factor

Zhonghua yi xue za zhi
Wan-li HuXin-min Zheng

Abstract

To explore the feasibility of erectile reflex circuit reconstruction by autologous vein graft combined with the use of insulin-like growth factor-I (IGF-I). 48 male adult Sprague-Dawley rats were randomized into 4 groups of 12 rats: group I (sham-operation group), undergoing operation to identify the bilateral cavernous nerves (CNs) only; group II (bilateral CN ablation group) in which the bilateral CNs of the length of at least 5 mm were ablated; group III (vein graft plus IGF-I group) in which the ablated CNs were repaired by autologous vein graft and IGF-I was injected into the venous cavity; and group IV (vein graft plus normal saline group), in which the ablated CNs were repaired and normal saline was injected instead. Four months later, apomorphine test was performed on each rat, and the erection times during the following half hour were recorded. After that, 4% fluoro-gold was injected into the bilateral corpus cavernosum of penis for each rat after anesthesia. Five days later, the rats were sacrificed and their bilateral major pelvic ganglia were obtained for detection of fluoro-gold by fluorescent microscopy. Apomorphine test showed an erection rate of 92% in group III, significantly higher than those of the group II (...Continue Reading

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