PMID: 7523610Jun 1, 1994Paper

Reconstruction of hippocampal CA1 pyramidal cell electrophysiology by computer simulation

Journal of Neurophysiology
E N WarmanG L Yuen

Abstract

1. We have developed a 16-compartment model that reproduces most of the features of the CA1 pyramidal cell electrophysiology observed experimentally. The model was constructed using seven active ionic conductances: gNa, gCa, gDR, gCT, gA, gM, and gAHP whose kinetics have been, inferred, in most cases, from the available voltage-clamp data obtained from these cells. We focussed the simulation on the initial and late accommodation, the slow depolarization potential and the spike broadening during repetitive firing, because their mechanisms are not well understood. 2. Current-clamp records were reproduced by iterative adjustments to the ionic maximum conductances, scaling and/or "reshaping" of the gates' time constant within the experimental voltage-clamp data, and shifting the position of the steady-state gate opening. The final properties of the ionic channels were not significantly different from the voltage-clamp experiments. 3. The resulting model reproduces all four after-potentials that have been recorded to follow activation of the cell. The fast, medium, and slow after-hyperpolarization potentials (AHPs) were, respectively, generated by ICT, IM, and IAHP. Furthermore, the model suggests that the mechanisms underlying the ...Continue Reading

Citations

Sep 6, 2001·Journal of Neurophysiology·W C Stacey, D M Durand
Nov 9, 2002·Journal of Neurophysiology·William C Stacey, Dominique M Durand
Jul 25, 2008·Journal of Neurophysiology·Michel RoyeckHeinz Beck
May 4, 2011·Journal of Computational Neuroscience·David Arthur StanleyWilliam L Ditto
Apr 12, 2000·Journal of Neurophysiology·P VaronaO Herreras
Sep 23, 2011·Journal of Computational Neuroscience·Xin ZouLiam Maguire
Jan 1, 1996·The European Journal of Neuroscience·A FigenschouJ F Storm
May 24, 2013·Journal of Neurophysiology·Sandeep PendyamSatish S Nair
Jan 26, 2018·Scientific Reports·Chia-Chu ChiangDominique M Durand
Mar 11, 2000·Journal of Neurophysiology·D DurstewitzT J Sejnowski
Mar 11, 2000·Journal of Neurophysiology·W C Stacey, D M Durand

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