Reconstruction of large rotator cuff tendon defects with porcine small intestinal submucosa in an animal model

Journal of Shoulder and Elbow Surgery
Charalampos G ZalavrasJames Tibone

Abstract

Large rotator cuff tears represent a challenging problem. The purpose of our study was to evaluate the small intestinal submucosa (SIS) extracellular matrix in reconstruction of such defects in an animal model. Forty rats were equally divided into an SIS group (reconstruction of a large supraspinatus tendon defect by use of the SIS) and a defect group (no repair). The operative and contralateral normal shoulders underwent histologic evaluation and biomechanical testing at 6 and 16 weeks. Neovascularization and fibroblastic ingrowth were present in SIS-regenerated tendons, which had an ultimate force to failure that was 78% of normal at 16 weeks. This was higher than in the defect group, which demonstrated an ultimate force to failure that was 34% of normal (P = .008). The ultimate force to failure of the SIS-regenerated tendons approached that of the normal tendon at 16 weeks. The SIS extracellular matrix served as a scaffold promoting host tissue ingrowth and appears promising in the management of large rotator cuff defects in a rat model. However, human beings sustain tears at the bone-tendon interface and demonstrate decreased healing potential relative to rats. Therefore, the findings of this preliminary study should not be...Continue Reading

References

Jul 1, 1989·The Journal of Surgical Research·S F BadylakL A Geddes
Jan 1, 1986·Clinical Orthopaedics and Related Research·J OzakiS Yoshimoto
Jan 1, 1968·Acta Orthopaedica Scandinavica·H V Heikel
Aug 1, 1995·Journal of Biomedical Materials Research·S F BadylakC Simmons
Jun 1, 1995·The Journal of Bone and Joint Surgery. American Volume·C A RockwoodW Z Burkhead
Jan 1, 1996·The Journal of Surgical Research·K M ClarkeS L Voytik
Feb 1, 1996·The Journal of Bone and Joint Surgery. American Volume·S E Karas, T L Giachello
Sep 1, 1996·Journal of Shoulder and Elbow Surgery·L J SoslowskyM R Moalli
Sep 30, 1998·Journal of Shoulder and Elbow Surgery·A G SchneebergerC Gerber
Dec 16, 1998·The American Journal of Sports Medicine·J E CarpenterL J Soslowsky
Jan 12, 1999·Journal of Shoulder and Elbow Surgery·J E CarpenterL J Soslowsky
Feb 10, 1999·Surgical Neurology·M A CobbF A Boop
Jun 24, 1999·Journal of Biomedical Materials Research·L M DejardinR B Clarke
Jul 2, 1999·Journal of Shoulder and Elbow Surgery·B TillanderR Norlin
Aug 31, 1999·The Journal of Bone and Joint Surgery. American Volume·A Miniaci, M MacLeod
Nov 5, 1999·Clinical Orthopaedics and Related Research·A I Caplan, V M Goldberg
Nov 5, 1999·Clinical Orthopaedics and Related Research·J E CarpenterL J Soslowsky
Nov 5, 1999·Clinical Orthopaedics and Related Research·S L WooJ H Wang
Nov 5, 1999·Clinical Orthopaedics and Related Research·S BadylakC Horvath
Mar 1, 1994·The Journal of the American Academy of Orthopaedic Surgeons·J P Iannotti
Jun 1, 2002·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·S ThomopoulosL J Soslowsky
Nov 27, 2002·Annals of Biomedical Engineering·Louis J SoslowskyJames E Carpenter
Mar 30, 2004·Journal of Biomechanics·Jonathan A GimbelLouis J Soslowsky
Sep 4, 2004·Clinical Orthopaedics and Related Research·Jonathan A GimbelLouis J Soslowsky

❮ Previous
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Citations

Dec 24, 2008·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Hemang YadavJohn D MacGillivray
Oct 24, 2012·Journal of Materials Science. Materials in Medicine·M F PietschmannP E Müller
Mar 6, 2008·La Chirurgia degli organi di movimento·Roberto RotiniRoberto Giardino
Sep 4, 2009·La Chirurgia degli organi di movimento·Stefano GuminaFranco Postacchini
Aug 12, 2009·Tissue Engineering. Part B, Reviews·Kathleen A DerwinJesse A McCarron
Jan 6, 2010·British Medical Bulletin·Umile Giuseppe LongoVincenzo Denaro
Aug 9, 2011·Sports Medicine and Arthroscopy Review·Umile Giuseppe LongoVincenzo Denaro
Nov 18, 2011·Sports Medicine and Arthroscopy Review·Umile Giuseppe LongoVincenzo Denaro
May 5, 2009·The Journal of Bone and Joint Surgery. American Volume·Kathleen A DerwinJoseph P Iannotti
Sep 4, 2013·Regenerative Medicine·Benjamin M DaviesAndrew Carr
Jul 9, 2008·Disability and Rehabilitation·Pankaj Sharma, Nicola Maffulli
Dec 17, 2011·Connective Tissue Research·Milena FiniDavide Melandri
Dec 17, 2008·Connective Tissue Research·Eleftherios TsiridisPeter V Giannoudis
Jun 25, 2013·Journal of Shoulder and Elbow Surgery·Johannes F PlateSandeep Mannava
Dec 3, 2014·Advanced Drug Delivery Reviews·Denitsa DochevaChristopher H Evans
Oct 13, 2012·Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association·Atsuyuki InuiHiroyuki Fujioka
Jan 17, 2012·Journal of Shoulder and Elbow Surgery·David P BeasonJoseph Bernstein
Jan 17, 2012·Journal of Shoulder and Elbow Surgery·Christian IsaacJohnny Huard
Dec 6, 2011·Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association·Matthew J SmithNicole P Waters
Dec 6, 2011·Biomaterials·Timothy J KeaneStephen F Badylak
Mar 2, 2010·Journal of Shoulder and Elbow Surgery·Kathleen A DerwinJoseph P Iannotti
Feb 5, 2010·Clinical Biomechanics·Jonathon H Yoder, Dawn M Elliott
Jun 3, 2009·Journal of Shoulder and Elbow Surgery·Brian R NeriYoung W Kwon
Jun 9, 2009·Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association·Junji IdeHiroshi Mizuta
Dec 29, 2007·Journal of Shoulder and Elbow Surgery·Yoshio IwataToshikazu Kubo
Jul 17, 2007·Journal of Shoulder and Elbow Surgery·Stephanie M PerryDavid L Glaser
Jun 15, 2007·Journal of Shoulder and Elbow Surgery·Amit AuroraKathleen Derwin
Jan 11, 2007·Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association·Shane J NhoJohn D MacGillivray
Jul 11, 2013·International Journal of Experimental Pathology·Osnat HakimiAndrew Carr
Dec 3, 2013·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Brian M SicariStephen F Badylak
Dec 9, 2008·Journal of Shoulder and Elbow Surgery·Junji IdeHiroshi Mizuta
Mar 29, 2014·Journal of Tissue Engineering and Regenerative Medicine·Timothy J Keane, Stephen F Badylak
Mar 14, 2014·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Juan PanTing-Wu Qin
May 10, 2016·Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association·Michael E SteinhausNikhil N Verma
Jul 28, 2016·Revista española de cirugía ortopédica y traumatología·A Jiménez-MartínS Pérez-Hidalgo
Oct 12, 2016·Scientific Reports·Kallyne K O MimuraSonia M Oliani
Dec 15, 2015·Orthopaedic Journal of Sports Medicine·Tanujan ThangarajahGordon W Blunn
May 2, 2019·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Sarah M KhatibzadehLinda A Dahlgren
Jul 11, 2020·The Journal of the American Academy of Orthopaedic Surgeons·Joo Y Sunwoo, George A C Murrell

❮ Previous
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