Reconstruction of mandibular defects using bone morphogenic protein: can growth factors replace the need for autologous bone grafts? A systematic review of the literature.

Plastic Surgery International
Alan S HerfordRahul Tandon

Abstract

Autogenous bone is still considered the "gold standard" of regenerative and reconstructive procedures involving mandibular defects. However, harvesting of this material can lead to many complications like increasing morbidity, expanding of the surgical time, and incomplete healing of the donor site. In the last few years many authors looked for the development of effective reconstruction procedures using osteoinductive factors without the need for conventional bone grafting. The first-in-human study involving the use of Bone Morphongenic Proteins (rhBMP) for mandibular reconstruction was performed in 2001 by Moghadam. Only few articles have been reported in the literature since then. The purpose of this study was to search and analyze the literature involving the use of rhBMP for reconstruction of mandibular defects. In all the studies reported, authors agree that the use of grown factors may represent the future of regenerative procedures with more research necessary for confirmation.

References

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Dec 2, 2010·The Journal of Craniofacial Surgery·Alan S Herford, Marco Cicciù

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Citations

Aug 8, 2014·Indian Journal of Dental Research : Official Publication of Indian Society for Dental Research·S M Balaji
May 13, 2014·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Zongyang SunMatthew J Allen
Jul 11, 2013·Clinical Implant Dentistry and Related Research·Henning Schliephake
May 9, 2015·Oral and Maxillofacial Surgery Clinics of North America·Alan S Herford, Katina Nguyen
Apr 27, 2017·Einstein·Henrique Celestino Lima E SilvaSérgio Luis de Miranda
Jul 30, 2017·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Paula Sanches SantosRumio Taga
Oct 19, 2016·The Journal of Oral Implantology·Erick Ricardo SilvaSamuel Porfírio Xavier
Nov 2, 2014·Clinical Oral Implants Research·Rafael R DiasSamuel P Xavier
Oct 17, 2019·Journal of Tissue Engineering and Regenerative Medicine·Qiang SunJill A Helms
Jan 1, 2021·Frontiers in Bioengineering and Biotechnology·Yongtao ZhangMostafa El Dafrawy

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Methods Mentioned

BETA
biopsy

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