Reconstruction of optical scanned images of inhomogeneities in biological tissues by Monte Carlo simulation

Computers in Biology and Medicine
J B Jeeva, Megha Singh

Abstract

The optical imaging of inhomogeneities located in phantoms of biological tissues, prepared from goat's isolated heart as control tissue and embedded with spleen and adipose tissues representing tumors, by Monte Carlo simulation, is carried out. The proposed scanning probe consists of nine units. Each unit is equipped with one photon injection port and three ports arranged in a straight line to collect backscattered photons emerging from various depths, and one port, placed coaxially to the source on the opposite side of the phantom, to collect the transmitted component. At each position of the grid, superposed on the tissue phantom, photons are introduced through source port into the phantoms and backscattered and transmitted photons are collected by respective ports. Based on the data collected from the entire grid surface the respective gray-level images are reconstructed. The inhomogeneity located at certain depth (2, 4, 6mm) is visualized in three images formed by the backscattered data collected by three ports. Increase or decrease in normalized backscattered intensity (NBI) observed in their scans corresponds to that of high scattering (adipose) or absorbing (spleen) inhomogeneity compared to that of control tissue and al...Continue Reading

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