Reconstruction of the postsubiculum head direction signal from neural ensembles

Hippocampus
Adam JohnsonA David Redish

Abstract

Head direction cells change their firing rates as a function of the orientation of an animal within an environment. Typically, these cells display a unimodal tuning curve with maximal firing at the cell's preferred direction. As different cells have different preferred directions, the population of cells has been hypothesized to represent the orientation of the animal within the environment. Previous research has shown that pairs of simultaneously recorded head direction cells respond similarly to cue manipulations, suggesting that a population of head direction cells acts in concert to represent the animal's orientation within its environment. Ensembles of head direction cells were recorded from the postsubiculum from rats foraging in an open field. Directional responses of each cell were quantified by the nonparametric Watson's U2 statistic, a measure which makes no explicit assumptions of tuning curve shape. Directionally responsive cells were then used to reconstruct each animal's orientation within the open field using population vector, optimal-linear estimator, and Bayesian methods. The results indicated that postsubiculum contained a complete representation of the animal's orientation. The internal consistency of a neur...Continue Reading

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Citations

Dec 25, 2013·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Tom HartleyJohn O'Keefe
Dec 25, 2013·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Hector J I PageSimon M Stringer
Jan 28, 2006·Journal of Biomechanical Engineering·R VenkateswaranA D Redish
Oct 21, 2009·PloS One·Zeb Kurth-Nelson, A David Redish
Feb 24, 2007·Bio Systems·Emilio Salinas, Nicholas M Bentley
Nov 21, 2008·Hippocampus·Edvard I Moser, May-Britt Moser
Aug 8, 2008·Hippocampus·Marianne FyhnMay-Britt Moser
May 31, 2013·The European Journal of Neuroscience·Jason R ClimerMichael E Hasselmo
Nov 15, 2011·Hippocampus·Siobhan Robinson, David J Bucci
Feb 1, 2005·Neuroscience·N Schmitzer-TorbertA D Redish
Mar 3, 2015·Nature Neuroscience·Adrien PeyracheGyörgy Buzsáki
Mar 3, 2017·Journal of Neurophysiology·William N Butler, Jeffrey S Taube
Sep 15, 2009·Nature Neuroscience·Dori DerdikmanEdvard I Moser
Mar 23, 2018·PLoS Computational Biology·Guillaume ViejoAdrien Peyrache

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