Reconstruction of ureteral defects with microvascular vein grafts in a rat model

Journal of Reconstructive Microsurgery
F ZhangW C Lineaweaver

Abstract

This study was undertaken to test the performance of an autologous vein graft as a ureteral replacement in the rat model. Twenty-six rats were divided into three groups. In Group 1 (n = 10), the animals had a 3-mm segment of the ipsilateral ureter excised and the ureteral defect repaired, using a superficial epigastric vein graft. In Group 2 (n = 10), the same ureteral defect was created and again repaired, using a superficial epigastric vein graft, with the addition of a Silastic stent. The control, Group 3 (n = 6), had the ureter transected and repaired solely by means of primary anastomosis. Animals from each group underwent urography and were sacrificed for histology at three different postoperative intervals: 1, 4, and 12 weeks. Postoperative urography results showed normal renal function in the animals with ureteral reconstruction using vein grafting aided by a stent, as well as in those with primary ureteral anastomosis. No renal function return was seen in the animals with ureteral reconstruction by vein grafting alone, without stent support. Histologically, a progressive loss of the vascular endothelium, and replacement with the urothelium typical of the ureter, was seen in the stented vein grafts. Severe ureteral obst...Continue Reading

Citations

Jul 20, 2007·Tissue Engineering·Marco Brito-JuarezGeorg C Bartsch
Aug 28, 2014·PloS One·Tomasz KloskowskiTomasz Drewa
Dec 17, 2003·Annals of Plastic Surgery·Chi-Cheng LiangYur-Ren Kuo
Jan 19, 2019·Journal of Tissue Engineering and Regenerative Medicine·Jan AdamowiczTomasz Drewa

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