Recording of the saphenous vein compliance by an ultrasonic echo-tracking device in the dog: effects of S 18149

British Journal of Pharmacology
C Vayssettes-CourchayT J Verbeuren

Abstract

1. Saphenous vein reactivity was recorded in the anaesthetized dog by use of an ultrasonic echo-tracking device to measure the internal diameter of the vein and to calculate the venous compliance. This method was used to investigate the effects of a new partial alpha1/alpha2-adrenoceptor agonist, S 18149, on the canine saphenous vein in vivo after intravenous (i.v.) or oral administration. 2. Venoconstrictions induced by i.v. or local administration of compounds were evaluated by continuous recording of the internal diameter of the saphenous vein with the echo-tracking method. Venous compliance was calculated in two ways: (1) as the slope of the diameter-pressure curve obtained by increasing the venous pressure with an inflatable cuff and (2) in veins in which pressure was higher than 12 mmHg, pulsatile variations in the venous diameter and venous pressure were detected and used to calculate the pulsatile compliance of the vein. 3. S 18149 administered i.v. at 0.5 microg kg(-1) min(-1) for 10 min induced a decrease in the saphenous vein diameter (-15+/-3%) and blood flow (-72+/-6%) associated with an increase in saphenous vein resistance; at the dose used, S 18149 did not modify venous pressure and caused only a weak increase i...Continue Reading

References

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Citations

Nov 25, 2000·European Journal of Pharmacology·C Vayssettes-CourchayT J Verbeuren
Jan 11, 2005·Journal of Applied Physiology·Patricia C E de GrootMaria T E Hopman
Jul 9, 2021·International Angiology : a Journal of the International Union of Angiology·Christine Vayssettes-Courchay

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