Recovering the triple coincidence of non-pure positron emitters in preclinical PET

Physics in Medicine and Biology
Hsin-Hon LinMeei-Ling Jan

Abstract

Non-pure positron emitters, with their long half-lives, allow for the tracing of slow biochemical processes which cannot be adequately examined by the commonly used short-lived positron emitters. Most of these isotopes emit high-energy cascade gamma rays in addition to positron decay that can be detected and create a triple coincidence with annihilation photons. Triple coincidence is discarded in most scanners, however, the majority of the triple coincidence contains true photon pairs that can be recovered. In this study, we propose a strategy for recovering triple coincidence events to raise the sensitivity of PET imaging for non-pure positron emitters. To identify the true line of response (LOR) from a triple coincidence, a framework utilizing geometrical, energy and temporal information is proposed. The geometrical criterion is based on the assumption that the LOR with the largest radial offset among the three sub pairs of triple coincidences is least likely to be a true LOR. Then, a confidence time window is used to test the valid LOR among those within triple coincidence. Finally, a likelihood ratio discriminant rule based on the energy probability density distribution of cascade and annihilation gammas is established to i...Continue Reading

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Sep 27, 2014·Physics in Medicine and Biology·Hsin-Hon LinMeei-Ling Jan
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Citations

Jan 15, 2019·Physics in Medicine and Biology·P MoskalB Zgardzińska
Sep 1, 2017·Nature Biomedical Engineering·Kathrin HeinzmannEric O Aboagye
Nov 13, 2020·Scientific Reports·Chih-Chieh ChiangHsin-Hon Lin

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