Recovery after a traumatic brain injury depends on diurnal variations effect of cystatin C

Neuroscience Letters
Marina Martinez-VargasLuz Navarro

Abstract

Many studies indicate that the hour of the day at which the onset of stroke occurs is very important in patient recovery. Furthermore, multiple studies have been conducted which show that ischemia in rats produces different magnitudes of injury depending on the hour of the day at which it was induced. Using a traumatic brain injury (TBI) model, we analyzed the effect of the time of day on the recovery of rats and obtained a higher survival rate if TBI was induced at 01:00 h as compared with TBI induced at 13:00 h. We also analyzed the effect of the protease inhibitor cystatin C (CC) on the recovery of rats from TBI and found that it increased mortality and bleeding, and that these effects were more pronounced at 13:00 h.

References

Mar 4, 2000·Neuropharmacology·A J HunterA A Parsons
Jul 7, 2000·Journal of Neurosurgery·P E VinallR H Rosenwasser
Sep 6, 2000·The Journal of Head Trauma Rehabilitation·A Verma
Jun 28, 2002·Brain Research. Brain Research Reviews·Ronen R Leker, Esther Shohami
Dec 14, 2002·Annals of the New York Academy of Sciences·Atsushi NagaiSeung U Kim
Jun 15, 2004·Brain Pathology·Ramesh Raghupathi

❮ Previous
Next ❯

Citations

Nov 30, 2013·International Journal of Molecular Sciences·Marina Martinez-VargasLuz Navarro
Apr 10, 2014·International Journal of Molecular Sciences·Marina Martinez-VargasLuz Navarro
Oct 2, 2012·Neuroscience Letters·Marina Martinez-VargasLuz Navarro
Aug 12, 2009·Neurobiology of Disease·Zachary M WeilRandy J Nelson
Jan 13, 2015·Brain, Behavior, and Immunity·Meriem SabirValérie Mongrain
Nov 3, 2020·Frontiers in Neuroscience·Ricardo Jesus Martinez-TapiaLuz Navarro
Apr 30, 2021·Proteomics. Clinical Applications·Eboni I LanceAllen D Everett

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.