Recovery after unilateral knee replacement due to severe osteoarthritis and progression in the contralateral knee: a randomised clinical trial comparing daily 2000 IU versus 800 IU vitamin D

RMD Open
Heike A Bischoff-FerrariDavid Felson

Abstract

To test whether daily high-dose vitamin D improves recovery after unilateral total knee replacement. Data come from a 24-month randomised, double-blind clinical trial. Adults aged 60 and older undergoing unilateral joint replacement due to severe knee osteoarthritis were 6-8 weeks after surgery randomly assigned to receive daily high-dose (2000 IU) or standard-dose (800 IU) vitamin D3. The primary endpoints were symptoms (Western Ontario and McMaster Universities Arthritis Index pain and function scores) assessed at baseline, 6, 12, 18 and 24 months in both knees, and the rate of falls over 24 months. The secondary outcomes were sit-to-stand performance, gait speed, physical activity and radiographic progression in the contralateral knee. We recruited 273 participants, 137 were randomised to receive 2000 IU and 136 were randomised to receive 800 IU vitamin D per day. 2000 IU vitamin D increased 25-hydroxyvitamin D levels to 45.6 ng/mL and 800 IU vitamin D to 37.1 ng/mL at month 24 (p<0.0001). While symptoms improved significantly in the operated knee and remained stable in the contralateral knee over time, none of the primary or secondary endpoints differed by treatment group over time. The rate of falls over 24 months was 1.05...Continue Reading

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Citations

Apr 7, 2020·The Journal of Bone and Joint Surgery. American Volume·Samantha M MeintsKristin L Schreiber
Jun 4, 2019·The American Journal of Clinical Nutrition·Simeon SchietzelHeike Annette Bischoff-Ferrari
Jun 17, 2020·The American Journal of Clinical Nutrition·Lauren A AbderhaldenHeike A Bischoff-Ferrari
Sep 27, 2019·Arthritis Care & Research·Gregor FreystaetterHeike A Bischoff-Ferrari
Sep 11, 2019·Journal of the American Medical Directors Association·Rahel ErnstHeike A Bischoff-Ferrari

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NCT00599807

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