Recovery following desflurane versus sevoflurane anesthesia for outpatient urologic surgery in elderly females

Anesthesiology and Pain Medicine
Michael S GreenGeorge Mychaskiw

Abstract

An unresolved question is the time required for the ability to return to complex tasks following anesthesia. This study aims to characterize the severity and duration of cognitive impairment following sevoflurane or desfluane anesthesia after brief surgery using tests of cognitive ability to objectively testing performance. This study is a double blinded randomized controlled trial. Patients were randomized to receive either a desflurane or sevoflurane-based anesthetic. On the morning of the surgery the subjects performed baseline cognitive task tests (Mini Mental Status exam, Trail Making Test Part A and B, Digit Symbol Coding, Hopkins Verbal Learning Test, Stroop Color and Word Test to determine baseline cognitive function. Cognitive testing was repeated 30 minutes and 1 hour after surgery whereas Modified Telephone Interview for Cognitive Status (TICS-M) and Memory Aging Telephone Screen (MATS) was used on the following day of surgery. Trail Making Test Part B cognitive test showed statistically significant in comparison for pre and post exposure of anesthetics. This difference was seen in the desflurane group. Other cognitive tests did not show differences on exposure to the anesthetic gases. This study questioned the diffe...Continue Reading

References

Mar 7, 2003·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·David R SinclairAlison Smiley
Sep 25, 2003·British Journal of Anaesthesia·J E HeavnerT King
Nov 24, 2005·Chest·Lan GaoGilbert Blaise
Jun 29, 2006·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Gregory L Bryson, Anna Wyand
Feb 28, 2007·Anesthesiology·Stanton NewmanMervyn Maze
Dec 25, 2007·Anesthesiology·Terri G MonkJoachim S Gravenstein
Sep 8, 2010·Annals of Neurology·Mario CibelliMervyn Maze
May 28, 2011·British Journal of Anaesthesia·A E Hudson, H C Hemmings
Feb 18, 2014·Journal of Safety Research·Loren StaplinKathy J Sifrit

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