Recovery from fixed-dose midazolam-induced anaesthesia and antagonism with flumazenil for outpatient arthroscopy

Acta Anaesthesiologica Scandinavica
W W ZuurmondJ H Helmers

Abstract

This study evaluated recovery after a fixed dose of midazolam as induction agent and the influence of flumazenil on recovery parameters in patients undergoing day-case surgery (arthroscopy of the knee). In 40 unpremedicated patients, anaesthesia was induced with midazolam 0.2 mg/kg, vecuronium bromide 0.1 mg/kg intravenously and 3 vol.% isoflurane in oxygen prior to intubation. Anaesthesia was maintained with nitrous oxide 66% in oxygen and 0.9 vol.% isoflurane. Ten minutes after the end of anaesthesia 20 patients received 0.2 mg flumazenil intravenously, followed by increments of 0.1 mg at 60 s intervals until eye opening. Recovery was assessed by the time to eye-opening, to answering five set questions correctly, and to recovering ocular balance (Maddox Wing test), and by comparing pre- and postoperative performance in a pencil and paper test (the p-deletion test). With the exception of ocular balance, all parameters showed a quicker improvement without side-effects in the flumazenil group. After 4 h all patients were fit for discharge. One month after the procedure, all patients were satisfied with the anaesthesia. Full recovery took on average 1.5 days (range between 0 h-10 days). Whilst the technique employing a fixed dose...Continue Reading

References

May 1, 1986·Acta Anaesthesiologica Scandinavica·W W Zuurmond, L van Leeuwen
May 1, 1986·Acta Anaesthesiologica Scandinavica·O K RoaldJ D Michenfelder
Apr 1, 1987·British Journal of Anaesthesia·D J SageR A Boas
Feb 1, 1973·British Journal of Anaesthesia·R A Dixon, J A Thornton
Feb 1, 1984·British Journal of Anaesthesia·M E CrawfordB O Mikkelsen
Sep 1, 1981·Anaesthesia·J A GambleL P Briggs

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Citations

Jan 1, 1994·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·H SprengerR S McLachlan
Feb 1, 1997·Journal of Clinical Anesthesia·A GuptaC Lennmarken
Jan 1, 1995·Acta Anaesthesiologica Scandinavica. Supplementum·R F McCloy
Jul 1, 1991·Oral Surgery, Oral Medicine, and Oral Pathology·S A CooperD McKenna
Jan 1, 1990·Acta Anaesthesiologica Scandinavica. Supplementum·P M Lauven, P J Kulka
Oct 1, 1990·DICP : the Annals of Pharmacotherapy·K A Karavokiros, G B Tsipis

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