PMID: 7031671Nov 1, 1981Paper

Recovery from prolonged abnormalities of canine myocardium salvaged from ischemic necrosis by coronary reperfusion

Proceedings of the National Academy of Sciences of the United States of America
R A KlonerE Braunwald

Abstract

The purpose of this study was to determine whether or not the biochemical, functional, and ultrastructural abnormalities produced by brief temporary coronary occlusions (unassociated with necrosis) ever resolve and, if so, when they do. Anesthetized open-chest dogs were subjected to 15 min of coronary artery occlusion followed by 72 hr, 7 days, or 14 days of reperfusion. Serial in vivo myocardial biopsies were performed for measurement of ATP and for ultrastructural analysis. Regional function was evaluated by sonomicrometry. Mean (+/- SEM) myocardial ATP concentration was 36.6 +/- 1.2 nmol/mg of cardiac protein in nonischemic subendocardium and 18.9 +/- 1.5 in ischemic subendocardium after 15 min of ischemia. ATP remainede performed for measurement of ATP and for ultrastructural analysis. Regional function was evaluated by sonomicrometry. Mean (+/- SEM) myocardial ATP concentration was 36.6 +/- 1.2 nmol/mg of cardiac protein in nonischemic subendocardium and 18.9 +/- 1.5 in ischemic subendocardium after 15 min of ischemia. ATP remainede performed for measurement of ATP and for ultrastructural analysis. Regional function was evaluated by sonomicrometry. Mean (+/- SEM) myocardial ATP concentration was 36.6 +/- 1.2 nmol/mg of car...Continue Reading

References

Jan 1, 1979·The American Journal of Cardiology·A C FoxB B Silk
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Jan 1, 1981·American Heart Journal·W GanzH J Swan
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Nov 1, 1980·The American Journal of Cardiology·J R Darsee, R A Kloner

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Citations

Mar 1, 1994·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·R J HicksM Schwaiger
Oct 1, 1991·Journal of the American College of Cardiology·C A NienaberM E Phelps
Aug 1, 1985·Journal of the American College of Cardiology·M SchwaigerM E Phelps
Nov 1, 1985·Journal of the American College of Cardiology·J J Gallagher
Mar 1, 1986·Journal of the American College of Cardiology·L C BeckerT Aversano
Nov 14, 1997·Journal of the American College of Cardiology·R Kalil-FilhoF Pileggi
Oct 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·E Brawnwald
Oct 22, 1998·Journal of Cardiovascular Pharmacology·S LaBrunoJ Kedem
Dec 30, 1998·Journal of Cardiovascular Pharmacology·J D SymonsS Schaefer
Oct 18, 1986·British Medical Journal·K Dickerson, P Hewitt
May 1, 1992·British Heart Journal·D A LythallC J Ilsley
Feb 22, 2011·American Journal of Physiology. Heart and Circulatory Physiology·R MitalR J Gumina
Jul 1, 1996·Molecular and Cellular Biochemistry·S M MoscaH E Cingolani
Dec 15, 2015·Nature Reviews. Cardiology·Liang-Han LingRoss J Hunter
May 29, 2013·The FEBS Journal·Vilmante BorutaiteGuy C Brown
Jul 1, 1985·International Journal of Cardiology·E E van der WallK I Lie
Apr 1, 1983·The Journal of Surgical Research·H B WardJ E Foker
Mar 1, 1986·The American Journal of Cardiology·D L PackerL D German
May 1, 1989·The American Journal of Cardiology·B J O'NeillA D Sharma
Apr 1, 2012·Journal of the Saudi Heart Association·M Al MehairiA Al Fagih

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