PMID: 7542551Mar 1, 1994Paper

Recovery from severe cyclic antidepressant overdose with hypertonic saline/dextran in a swine model

Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine
J L McCabeT E Auble

Abstract

To determine the effect of a hypertonic saline and dextran (HSD) solution on blood pressure and QS duration during severe cyclic antidepressant (CA) toxicity in swine. Ten domestic swine weighing 20-24 kg were anesthetized and placed on mechanical ventilation. Nortriptyline solution was infused intravenously to achieve hypotension (systolic blood pressure equal to 50% of baseline) and a QRS duration of 120 msec. After reaching toxicity, the animals received in a randomized fashion either 10 mL/kg of a 7.5% saline/6% dextran solution or an equal volume of 0.9% saline as a rapid intravenous bolus. The animals were observed for one hour or until they died. Blood pressure and ECG were recorded continuously. Arterial pH was maintained in the physiologic range by controlled ventilation. Mean systolic blood pressure 10 minutes after treatment was 45 +/- 8 torr in the normal- saline group compared with 115 +/- 12 torr in the HSD group (p < 0.05). Mean QRS duration 10 minutes after treatment was 180 +/- 8 msec in the normal-saline group; it was 88 +/- 13 msec in the HSD group (p < 0.05). All normal-saline--group animals died within 20 minutes, and four of the five animals in the HSD group survived to 60 minutes (p < 0.05). The mean peak...Continue Reading

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Citations

Oct 23, 1997·Critical Care Medicine·E L LiebeltA Woolf
Oct 24, 2000·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·J L KaplanL De Garavilla
Jun 24, 2008·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Cenker Eken
Oct 20, 2010·Drug and Chemical Toxicology·Kubilay OransayYesim Tuncok
Sep 2, 2006·Journal of Intensive Care Medicine·David P BettenRichard F Clark
Jan 2, 2008·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Vikhyat S Bebarta, Javier C Waksman
May 9, 2008·Emergency Medicine Australasia : EMA·Colin J Banks, Jeremy S Furyk
Jun 1, 2021·Critical Care Clinics·Maude St-Onge
Jul 1, 1995·Annals of Emergency Medicine·C K StoneR Low

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