Recovery from welding-fume-exposure-induced MRI T1 signal intensities after cessation of welding-fume exposure in brains of cynomolgus monkeys

Inhalation Toxicology
Jeong Hee HanIl Je Yu

Abstract

The shortening of the MRI T1 relaxation time, indicative of a high signal intensity in a T1-weighted MRI, is known as a useful biomarker for Mn exposure after short-term welding-fume exposure. A previous monkey experimental study found that the T1 relaxation times decreased time-dependently after exposure, and a visually detectable high signal intensity appeared after 150 days of exposure. The nadir for the shortening of the T1 relaxation time was also previously found to correspond well with the blood Mn concentration in welders, suggesting a correlation between a prolonged high blood Mn concentration and shortened T1 relaxation time. Accordingly, to clarify the clearance of the brain Mn concentration after the cessation of welding-fume exposure, cynomolgus monkeys were assigned to 3 groups-unexposed, low dose (31 mg/m(3) total suspended particulate (TSP), 0.9 mg Mn/m(3)), and high dose (62 mg/m(3) TSP, 1.95 mg Mn/m(3))-and exposed to manual metal-arc stainless steel (MMA-SS) welding fumes for 2 h per day for 8 mo in an inhalation chamber system equipped with an automatic fume generator. After reaching the peak MRI T1 signal intensity (shortest T1 relaxation time), the monkeys were allowed to recover by ceasing the welding-fum...Continue Reading

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Citations

Sep 26, 2013·Particle and Fibre Toxicology·Ji Hyun LeeIl Je Yu
Dec 7, 2013·Inhalation Toxicology·Choong Yong KimIl Je Yu
Apr 29, 2015·Neurotoxicology·Susan R CriswellBrad A Racette
Jul 29, 2016·Toxicological Sciences : an Official Journal of the Society of Toxicology·Eun-Young LeeXuemei Huang
Jan 11, 2019·Toxicological Sciences : an Official Journal of the Society of Toxicology·Eun-Young LeeXuemei Huang
Mar 20, 2020·The Journal of Biological Chemistry·Rekha C BalachandranAaron B Bowman
Feb 23, 2019·International Archives of Occupational and Environmental Health·Dag G EllingsenValery Chashchin
Nov 29, 2021·Neurochemical Research·Yu-Min CaoQi-Yuan Fan

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