PMID: 6980339Apr 1, 1982Paper

Recovery of age-dependent immunological deterioration in Balb/c mice by short-term treatment with L-thyroxine

Mechanisms of Ageing and Development
N FabrisE Mocchegiani

Abstract

The progressive decline of immune efficiency with advancing age has been investigated in Balb/c mice by measuring the spleen-cell responsiveness to both T- and B-mitogens and the capacity to form plaques after immunization with sheep erythrocytes. While the responsiveness to concanavalin A and lipopolysaccharide is not significantly decreased in old mice, the responsiveness to phytohaemagglutinin and the plaque-forming-cell capacity progressively diminish with advancing age. Such a functional decline has been correlated with the age-associated deterioration of the neurohormonal balance and particularly with the reduction of thyroxine blood levels. Reconstitution experiments carried out by treating animals of increasing ages with 15 daily injections of L-thyroxine have demonstrated that such a treatment is able to restore the age-related decline of immune efficiency, and that this recovery is associated with the reactivation of the thymic endocrine activity. These data are consistent with the idea that the neurohormonal balance may influence the immune efficiency and that its derangement with advancing age may represent one of the factors responsible for the aging of the immune system.

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Citations

Sep 1, 1985·Biulleten' eksperimental'noĭ biologii i meditsiny·Iu I BorodinIu P Shorin
Dec 31, 1991·Mechanisms of Ageing and Development·R G GoyaJ Meites
Jun 14, 1991·Mechanisms of Ageing and Development·M H LuR W Hart
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Jan 1, 1986·International Journal of Immunopharmacology·N FabrisS Piloni
Dec 26, 1992·Annals of the New York Academy of Sciences·R BrunelliG Doria
Nov 21, 1992·Annals of the New York Academy of Sciences·N Fabris
Apr 15, 1992·Annals of the New York Academy of Sciences·E Mocchegiani, N Fabris
May 31, 1994·Annals of the New York Academy of Sciences·N Fabris
May 11, 2006·Journal of Animal Physiology and Animal Nutrition·K A El-ShaikhG A Othman
Aug 11, 1998·Biochemical Pharmacology·J R Klein
Jan 1, 1988·Annals of the New York Academy of Sciences·N FabrisM Provinciali
Aug 15, 2006·Ageing Research Reviews·Eugenio MocchegianiMarco Malavolta
Oct 26, 2005·General and Comparative Endocrinology·Shiv Shankar SinghSeema Rai
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Feb 1, 1990·Journal of Endocrinological Investigation·E MocchegianiN Fabris
Feb 1, 1990·Journal of Endocrinological Investigation·M Provinciali, N Fabris

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