Recovery of consciousness after severe brain injury: the role of arousal regulation mechanisms and some speculation on the heart-brain interface

Cleveland Clinic Journal of Medicine
N D Schiff

Abstract

Recovery of consciousness after severe brain injury involves reconstitution of brain arousal mechanisms and cerebral integrative function. This review discusses several aspects of neuroanatomy and neuropathology relevant to the process of recovery. Particular emphasis is placed on the role of the anterior forebrain and circuit mechanisms linking the frontal lobe, striatum, and central thalamus. The article concludes with some observations on the heart-brain interface and future research directions in the context of recovery from severe brain injury.

Citations

Dec 21, 2012·Neuroscience and Biobehavioral Reviews·Georg Northoff
Oct 29, 2011·Neurologic Clinics·Ron Hirschberg, Joseph T Giacino
Oct 22, 2014·Journal of Neurotrauma·Francesca PistoiaAntonio Carolei
May 1, 2015·PloS One·Natia JaparidzeMichael Siniatchkin
Jul 2, 2011·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jean-Pierre Changeux, Hans C Lou
Jan 1, 2016·Neurocritical Care·Calvin Tucker, Kirsten Sandhu
Sep 14, 2017·Current Opinion in Neurology·Caroline Schnakers, Martin M Monti

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