Recovery of consciousness following acute symptomatic seizures due to central nervous system infections in children

Developmental Medicine and Child Neurology
Eleanor J KingJohn C Taylor

Abstract

The aim of this study was to assess whether acute symptomatic epileptic seizures associated with central nervous system infections (AS(inf) ) have a different ictal and postictal course to seizures of other aetiologies. A case note analysis of 81 children (47 males; 34 females; age range 1mo-15y 6mo; median age 12mo) with central nervous system infections was undertaken. Seizure type, duration, aetiology, and timing were recorded. Recovery time to full consciousness in those not intubated was determined. Intubation rates and recovery times were compared with those from previous studies. Of the 81 children, 40 (49.4%) had one or more AS(inf) . The different aetiologies were bacterial meningitis, aseptic meningitis, abscess/empyema, encephalitis, and postoperative infection. Twenty-two had status epilepticus. The intubation rate in children with AS(inf) was higher than that in children with seizures of other aetiologies (21/40 [52.5%] vs 4/124 [3.23%]; p < 0.0001). Median postictal recovery time was 4.33 hours (0-207h). Children with AS(inf) took 4.3 (p<0.01), 3.0 (p=0.004), and 8.8 (p<0.001) times longer to recover than children who had seizures from all causes, remote symptomatic seizures, and febrile seizures respectively. AS(...Continue Reading

Citations

Jul 24, 2013·Proceedings of the National Academy of Sciences of the United States of America·Maike KittelmannAlexander Gottschalk
Sep 14, 2012·Epilepsia·J Helen Cross
Feb 23, 2012·Developmental Medicine and Child Neurology·Tony McShane
Jun 25, 2014·Seizure : the Journal of the British Epilepsy Association·Bo ZhouDong Zhou

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