PMID: 9523814Apr 2, 1998Paper

Recovery of evoked potential amplitude after cerebral arterial air embolism in the rabbit: a comparison of the effect of cardiopulmonary bypass with normal circulation

Anesthesiology
B J HindmanJ Cutkomp

Abstract

Cerebral arterial air embolism (CAAE) may cause neurologic injury during cardiac surgery. It is not known whether cardiopulmonary bypass (CPB) increases or decreases brain injury from CAAE compared with the normal circulation. A model of CAAE was produced by injection of 50 microl/kg air into the internal carotid artery of methohexital-anesthetized New Zealand white rabbits. Somatosensory-evoked potential (SSEP) amplitude was measured serially as a marker of neurologic recovery. In experiment A, saline rather than air was injected to control for surgical manipulation and time in CPB (n = 4) and nonheparinized non-CPB (n = 4) animals. In experiment B, 50 microl/kg air was injected in CPB (n = 11) and nonheparinized non-CPB (n = 11) animals. In experiment C, non-CPB animals (n = 6) were given heparin according to the same protocol as for CPB. In experiment A, SSEP latencies and amplitudes did not differ between CPB and non-CPB conditions. In experiment B, there was no SSEP recovery 5 min after CAAE in either CPB or non-CPB animals. Thereafter, SSEP recovery was less in CPB animals than in non-CPB animals at 30 min (9 +/- 12% vs. 29 +/- 20%; P = 0.009) and 60 min (18 +/- 15% vs. 39 +/- 22%; P = 0.030) after CAAE. Ninety-minute SSE...Continue Reading

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Citations

May 13, 1999·Anesthesiology·B J Hindman, M M Todd
Jul 29, 2003·Anesthesiology·Akira Suzuki, David M Eckmann
Sep 10, 2003·Anesthesiology·Naomi Sta Maria, David M Eckmann
May 6, 2005·Journal of Vascular and Interventional Radiology : JVIR·David B KozlovUmberto De Girolami
Jan 28, 2012·Journal of Neuroscience Methods·Robert P WeeninkRobert A van Hulst
May 19, 2010·Seminars in Cardiothoracic and Vascular Anesthesia·Bettina Jungwirth, Fellery de Lange

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