Recovery of impaired pretreatment spermatogenesis in testicular cancer

Fertility and Sterility
S D FossåT Aabyholm

Abstract

Light microscopic sperm analysis was done 24 months after treatment or later in 25 patients with testicular cancer with azoospermia or severe oligospermia (sperm cell count less than 10 x 10(6)/mL) after orchiectomy before further treatment. Treatment after orchiectomy consisted of abdominal irradiation, cisplatin-based chemotherapy, retroperitoneal surgery, a combination of the former treatment modalities, or a surveillance policy. At the time of post-treatment reassessment, 15 of the 25 patients had sperm cell concentrations of at least 10 x 10(6)/ml (7 of 14 patients in the azoospermia group; 8 of 11 patients in the oligospermia group). Eight patients fathered a child after discontinuation of treatment for testicular cancer. Recovery of spermatogenesis could be seen after all types of treatment. A highly increased pretreatment serum follicle-stimulating hormone was correlated with lack of sperm cell production recovery.

Citations

Mar 17, 2010·Hematological Oncology·Marleen A E van der KaaijHanneke C Kluin-Nelemans
Dec 1, 1999·Current Opinion in Urology·S D FossåC F Haaland
Nov 24, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·S D FossåS P Stenning
Jul 31, 2019·JNCI Cancer Spectrum·Philip D PoorvuAnn H Partridge
May 7, 1999·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·G Gruber, N Schwegler
Feb 17, 2005·Journal of Andrology·Walter Albrecht, Maria De Santis
May 9, 2007·The Urologic Clinics of North America·Sarah M Lambert, Harry Fisch

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