PMID: 18727414Aug 30, 2008Paper

Recovery of instrumental conditional reflexes in rats after pyramidotomy and action of bacterial melanin

Zhurnal evoliutsionnoĭ biokhimii i fiziologii
L P ManvelianT R Petrosian

Abstract

Unilateral pyramidotomy at the bulbar level performed after preliminary elaboration of instrumental conditional reflex (ICR) and without its elaboration caused hemiparesis of extremities in rats. Next day after this operation a half of the operated animals both with elaborated ICE and without its elaboration was injected intramuscularly with bacterial melanin solution (170 mg/kg). Comparison of terms of recovery of ICR and of a balancing movement of the paralyzed hindleg in the operated rats without administration of melanin and with its injection showed that in the "melanin" animals the time of posttraumatic rehabilitation was much shorter and recovery of movement occurred faster and more completely. It has been found that the difference in terms of recovery of rat motor functions in this case is due to the protector action of bacterial melanin.

References

Jan 1, 1988·Journal of Neuropathology and Experimental Neurology·K D BarronR Mankes
Sep 14, 1999·Brain Research Bulletin·J W Fawcett, R A Asher
Oct 26, 2000·Proceedings of the National Academy of Sciences of the United States of America·D SulzerL Zecca
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May 29, 2002·Neuroscience·R ChenM Hallett
Aug 31, 2006·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Irin C Maier, Martin E Schwab

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Citations

Mar 20, 2015·Neural Regeneration Research·Olga V GevorkyanAnichka S Hovsepyan
Nov 9, 2014·Biotechnology Letters·Estibaliz Sansinenea, Aurelio Ortiz

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