Recovery of intentional dynamic balance function after intravenous sedation with midazolam in young and elderly subjects

European Journal of Anaesthesiology
T FujisawaK Fukushima

Abstract

Computerized dynamic posturography using an intentional postural-sway task can be used to assess body-leaning ability and postural-control ability to prevent falls. Falls are the leading cause of morbidity and mortality for the elderly. The purpose of the present study was to evaluate the recovery of intentional dynamic balance function after intravenous sedation with midazolam in elderly subjects in comparison with that in young subjects. Midazolam was administered in small, divided doses over 4-5 min until the Wilson sedation score reached three in 20 young and 18 elderly male volunteers. The dynamic limits of the stability test, in which subjects leaned their body intentionally as indicated by a cursor moving on a computer screen, was determined before (baseline) and 50, 70, 90, 110, and 130 min after administration of midazolam. The changes from baseline values of path sway and movement time 50 min after the administration of midazolam in elderly subjects (106.8 +/- 101.0%, 4.6 +/- 3.0 s; mean +/- SD) were significantly greater than those (32.9 +/- 87.2%, 1.9 +/- 2.8 s) in young subjects (P = 0.024, P = 0.008), respectively. The elderly show slower recovery of the intentional dynamic balance function than do young adults af...Continue Reading

References

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Jan 28, 2005·Journal of Anesthesia·Toshiaki FujisawaKazuaki Fukushima

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Citations

Feb 1, 2019·Anesthesia Progress·UNKNOWN Working Group on Guidelines Development for Intravenous Sedation in Dentistry, the Japanese Dental Society of Anesthesiology
May 16, 2020·Journal of the American Animal Hospital Association·Min JangInhyung Lee

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