Recovery of long-term denervated human muscles induced by electrical stimulation

Muscle & Nerve
Helmut KernUgo Carraro

Abstract

We investigated the restorative potential of intensive electrical stimulation in a patient with long-standing quadriceps denervation. Stimulation started 18 months after injury. After 26 months, the thighs were visibly less wasted. Muscle cross-sectional areas, measured by computerized tomography, increased from 36.0 cm(2) to 57.9 cm(2) (right) and from 36.1 cm(2) to 52.4 cm(2) (left). Knee torque had become sufficient to maintain standing without upper extremity support. Biopsies revealed evidence of both growth and regeneration of myofibers. The results suggest that electrical stimulation may offer a route to the future development of mobility aids in patients with lower motor neuron lesions.

Citations

Mar 10, 2006·European Journal of Applied Physiology·Julien GondinAlain Martin
May 2, 2006·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Doreen K JacobMarlin H Mickle
Feb 24, 2005·Artificial Organs·Stanley SalmonsJonathan C Jarvis
Sep 11, 2008·Artificial Organs·Stanley Salmons, Jonathan C Jarvis
Mar 5, 2008·The Journal of Clinical Investigation·Jo C Bruusgaard, Kristian Gundersen
Jan 1, 2011·Journal of medical and biological engineering·Michael P WillandJames R Bain
Apr 10, 2008·Neurological Research·Donatella BiralUgo Carraro
Dec 6, 2012·Canadian Journal of Physiology and Pharmacology·Qing-Qing ChenWei-Zhong Zhu
Dec 10, 2013·Journal of Voice : Official Journal of the Voice Foundation·Marco GuzmanCristina Jackson-Menaldi
Jun 17, 2009·Cytotherapy·Jorge A GenoveseAmit N Patel
Jun 2, 2009·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·Nektarios SinisDoychin N Angelov
Apr 21, 2009·Journal of AAPOS : the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus·Federico G VelezBrian T Hahn
Jan 26, 2016·Neural Regeneration Research·Krzysztof SuszyńskiDariusz Górka
May 6, 2008·Journal of Electromyography and Kinesiology : Official Journal of the International Society of Electrophysiological Kinesiology·A BotterM A Minetto
Apr 4, 2008·Biochemical and Biophysical Research Communications·Jorge A GenoveseAmit N Patel
Nov 2, 2005·The Veterinary Clinics of North America. Small Animal Practice·Natasha OlbyTeresa R Glick
Feb 15, 2007·Muscle & Nerve·Lynne R Sheffler, John Chae
Jun 20, 2008·Muscle & Nerve·Zoe AshleyStanley Salmons
Oct 4, 2007·Muscle & Nerve·Kathrin DopplerAntje Bornemann
Jul 10, 2013·Macromolecular Bioscience·Antonella SilvestriGianluca Ciardelli
Mar 13, 2008·IEEE Transactions on Bio-medical Engineering·Frank Rattay
Sep 18, 2015·Journal of Muscle Research and Cell Motility·M SciancaleporeG Taccola
Aug 9, 2005·Trends in Neurosciences·Richard B Stein, Vivian Mushahwar
Aug 30, 2014·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·GyuHyun JinGeunHyung Kim
Apr 5, 2011·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·Emmanouil SkourasDoychin N Angelov
Jun 7, 2015·Journal of Neuroengineering and Rehabilitation·Karin PieberOthmar Schuhfried
Jan 14, 2017·PM & R : the Journal of Injury, Function, and Rehabilitation·Shin-Seung YangMin Kyun Sohn
Mar 28, 2017·Muscle & Nerve·Eun Sil KohJae-Young Lim
May 6, 2010·Clinical Rehabilitation·Gita M Ramdharry

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.