Recovery of lordotic activity by dorsal deafferentation of the preoptic area in male and androgenized female rats

Physiology & Behavior
Y KondoY Arai

Abstract

Lordotic activity was examined in male and neonatally androgenized female rats following dorsal deafferentation of the preoptic area (POA). Female pups were injected with various doses (100, 250, 500, or 1000 micrograms) of testosterone propionate (TP) on day 3 postpartum. Ten weeks after birth, all animals were castrated, then half of the castrated males and females in each group were subjected to dorsal deafferentation of the POA (anterior roof deafferentation: ARD) by using an L-shaped Halász knife in order to transect the dorsal forebrain efferents which are thought to exert an inhibitory influence on the lordosis mediating mechanism. Animals were implanted subcutaneously with Silastic tubes containing estradiol-17 beta (E2). Observations of lordosis behavior were carried out 5, 10, and 15 days after implantation of E2. Three to six hours before each behavioral test, all rats were injected with 0.5 mg progesterone. Regardless of the dose of TP given neonatally, androgenized females, as well as males, showed low levels of lordotic behavior. In contrast, males with ARD and androgenized females with ARD displayed lordosis more frequently than males without ARD, and androgenized females without ARD. Lordotic activity in the and...Continue Reading

References

Jul 1, 1979·Brain Research Bulletin·J F Rodriguez-Sierra, E Terasawa
Feb 1, 1977·Pharmacology, Biochemistry, and Behavior·D M NanceR A Gorski
Apr 16, 1976·Brain Research·D T Modianos, D W Pfaff
Jun 1, 1983·Endocrinologia Japonica·A Matsumoto, Y Arai

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Citations

Jan 1, 1993·Brain Research. Brain Research Reviews·S Segovia, A Guillamón
Aug 25, 2004·Hormones and Behavior·Kai XiaoYasuo Sakuma

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