Recovery of Na-glucose cotransport activity after renal ischemia is impaired in mice lacking vimentin

American Journal of Physiology. Renal Physiology
Isabelle RunembertFabiola Terzi

Abstract

Vimentin, an intermediate filament protein mainly expressed in mesenchyma-derived cells, is reexpressed in renal tubular epithelial cells under many pathological conditions, characterized by intense cell proliferation. Whether vimentin reexpression is only a marker of cell dedifferentiation or is instrumental in the maintenance of cell structure and/or function is still unknown. Here, we used vimentin knockout mice (Vim(-/-)) and an experimental model of acute renal injury (30-min bilateral renal ischemia) to explore the role of vimentin. Bilateral renal ischemia induced an initial phase of acute tubular necrosis that did not require vimentin and was similar, in terms of morphological and functional changes, in Vim(+/+) and Vim(-/-) mice. However, vimentin was essential to favor Na-glucose cotransporter 1 localization to brush-border membranes and to restore Na-glucose cotransport activity in regenerating tubular cells. We show that the effect of vimentin inactivation is specific and results in persistent glucosuria. We propose that vimentin is part of a structural network that favors carrier localization to plasma membranes to restore transport activity in injured kidneys.

References

Apr 1, 1992·Kidney International·F VrtovsnikG Friedlander
Jan 1, 1992·Kidney International·F G Toback
Jun 1, 1991·The American Journal of Physiology·B A Molitoris
Aug 1, 1990·The American Journal of Physiology·P S KellermanB A Molitoris
Dec 30, 1988·Biochemical and Biophysical Research Communications·P B HatzingerJ L Stevens
Mar 1, 1989·The American Journal of Physiology·D M SpiegelB A Molitoris
Oct 1, 1989·The Journal of Clinical Investigation·B A MolitorisR H Dahl
Dec 1, 1985·The Journal of Clinical Investigation·B A MolitorisF R Simon
Sep 1, 1987·The Journal of Clinical Investigation·B A Molitoris, R Kinne
Sep 1, 1974·The Biochemical Journal·A G Booth, A J Kenny
Feb 1, 1984·The American Journal of Physiology·P A JohnstonN G Levinsky
Dec 8, 1995·The Journal of Biological Chemistry·G YouM A Hediger
Dec 1, 1994·The American Journal of Physiology·M AbbateD Brown
Jul 1, 1994·The American Journal of Physiology·S K Van WhyM Kashgarian
Mar 15, 1997·The Journal of Clinical Investigation·H ChiaoR A Star
Sep 18, 1997·The Journal of Clinical Investigation·F TerziG Friedlander
Mar 21, 1998·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·R M Evans
Apr 29, 1998·Journal of the American Society of Nephrology : JASN·Z WangM Soleimani
Aug 5, 1998·Current Opinion in Nephrology and Hypertension·S K Van Why, N J Siegel
Feb 20, 1999·International Journal of Oncology·S PrasadA Dritschilo
Oct 19, 1999·Molecular and Cellular Biology·E J SmartM P Lisanti
Jun 3, 2000·American Journal of Physiology. Renal Physiology·T H KwonS Nielsen
Sep 7, 2000·The Journal of Clinical Investigation·G L Semenza
Jan 3, 2001·American Journal of Physiology. Renal Physiology·E M Wright
Dec 12, 2001·Kidney International·J DengR A Star
Apr 23, 2002·Kidney International·Richard A ZagerVivian dela Rosa
May 23, 2003·Journal of the American Society of Nephrology : JASN·Joseph V Bonventre
Jul 23, 2003·Journal of the American Society of Nephrology : JASN·Joseph V Bonventre, Joel M Weinberg

❮ Previous
Next ❯

Citations

Jan 24, 2006·Nature Cell Biology·Mikko NieminenSirpa Jalkanen
Dec 8, 2009·Nature Medicine·Francisco VerdeguerMarco Pontoglio
Oct 22, 2008·Toxicological Sciences : an Official Journal of the Society of Toxicology·Christine DieterichHanna H Ng
Jan 1, 2014·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Eric D MorrellNúria M Pastor-Soler
Jan 5, 2010·Trends in Cell Biology·D M ToivolaM B Omary
May 22, 2007·Experimental Cell Research·Johanna IvaskaJohn E Eriksson
Jun 7, 2007·Nature Reviews. Molecular Cell Biology·Harald HerrmannUeli Aebi
Oct 13, 2006·American Journal of Physiology. Renal Physiology·Christoph SchmidtMichael Bucher
Feb 8, 2008·American Journal of Physiology. Cell Physiology·Dale D Tang
Sep 30, 2014·Physiological Reports·Pamella A MalagrinoAlexandre C Pereira
Dec 7, 2018·F1000Research·Rachel A BattagliaNatasha T Snider
Apr 11, 2018·American Journal of Physiology. Renal Physiology·Zheng WangReynold I Lopez-Soler
Nov 16, 2020·Cytoskeleton·Christopher S Morrow, Darcie L Moore
Dec 24, 2005·European Journal of Cell Biology·Ruth SchietkeThomas M Magin

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.