Recovery of OATP1B Activity after Living Kidney Transplantation in Patients with End-Stage Renal Disease

Pharmaceutical Research
Yosuke SuzukiHiroki Itoh

Abstract

Recently, several studies have shown that renal failure decreases the metabolic clearance of drugs and the transportation capability of some drug transporters. However, whether organic anion transporting polypeptide (OATP)1B activities decrease in renal failure remains unknown. In this study, we measured plasma concentrations of coproporphyrin-I (CP-I), a specific endogenous OATP1B probe, in patients with end stage renal disease before and after living kidney transplantation and evaluated the effect of renal function on OATP1B activity. This prospective study recruited 13 patients with end-stage renal disease. Plasma CP-I concentrations were measured before and 7, 14, 30 and 90 days after living kidney transplantation. Plasma CP-I concentrations decreased over time after living kidney transplantation and showed significant difference on day 90 compared with before living kidney transplantation [1.12 ± 0.59 vs 0.65 ± 0.27 ng/mL, p < 0.05 (95% CI of difference - 0.927, -0.013)]. A significant negative correlation was observed between estimated glomerular filtration rate and plasma CP-I concentration (r = -0.30, p < 0.05), suggesting recovery of OATP1B activity with improvement in renal function. OATP1B activity may decrease in re...Continue Reading

References

Nov 14, 2002·British Journal of Pharmacology·Carl GuévinVincent Pichette
Jun 18, 2003·Clinical Pharmacology and Therapeutics·Yohei NishizatoYuichi Sugiyama
Nov 19, 2003·Pharmaceutical Research·Bhaskar RegeMohamadi A Sarkar
Aug 3, 2004·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Hong SunLeslie Z Benet
Apr 22, 2005·British Journal of Clinical Pharmacology·Mikko NiemiMartin F Fromm
Apr 30, 2005·International Journal of Cardiology·Vincent Launay-VacherGilbert Deray
Jun 18, 2005·Clinical Pharmacology and Therapeutics·Mikko NiemiPertti J Neuvonen
Aug 13, 2005·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·W P D LemahieuB D Maes
Oct 4, 2005·Clinical Pharmacology and Therapeutics·Edmund LeeDennis Schneck
Oct 4, 2005·Clinical Pharmacology and Therapeutics·Jae-Yong ChungIn-Jin Jang
Nov 17, 2006·Pharmacogenetics and Genomics·Marja K PasanenMikko Niemi
May 3, 2007·Clinical Pharmacology and Therapeutics·M K PasanenM Niemi
Oct 18, 2007·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Judith NaudVincent Pichette
Jan 9, 2008·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Soichiro MatsushimaYuichi Sugiyama
Oct 11, 2008·Journal of Pharmacological Sciences·Josée MichaudVincent Pichette
Aug 22, 2009·Journal of the American Society of Nephrology : JASN·Thomas D NolinJonathan Himmelfarb
Mar 2, 2010·Nature Reviews. Drug Discovery·UNKNOWN International Transporter ConsortiumLei Zhang
Apr 27, 2010·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Masaru HorioSeiichi Matsuo
Apr 29, 2011·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Judith NaudVincent Pichette
Feb 22, 2012·Biopharmaceutics & Drug Disposition·Jun-ichi KusabaTetsuya Aiba
Dec 3, 2014·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Benjamin K A ThomsonBradley L Urquhart
Sep 19, 2015·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Dallas Bednarczyk, Carri Boiselle
Feb 26, 2016·The Journal of Pharmacology and Experimental Therapeutics·Hong ShenYurong Lai
Dec 15, 2017·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Emmanuel Njumbe EdiageTom Verhaeghe

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Citations

Jul 30, 2020·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Yueping ZhangHong Shen
Nov 1, 2020·The Journal of Pharmacology and Experimental Therapeutics·Sagnik ChatterjeeHong Shen

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