Recovery of photoreceptor outer segments after anti-VEGF therapy for age-related macular degeneration.

Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie
Akio OishiYasuo Kurimoto

Abstract

To evaluate whether the status of the external limiting membrane (ELM) or inner segment/outer segment junction (IS/OS) improves after intravitreal injection of ranibizumab for age-related macular degeneration (AMD). We also evaluated whether the pre-operative values of these parameters are associated with the visual prognosis. This was a hospital-based, cross-sectional study. Seventy-six eyes of 76 treatment-naive AMD patients who received three monthly intravitreal injections of ranibizumab followed for more than 6 months with additional as-needed injections were investigated. Spectral domain OCT was used to evaluate the length of ELM, IS/OS, and foveal thickness pre- and post-operatively. Changes of ELM and IS/OS length were evaluated postoperatively. Correlation coefficients between pre-operative parameters and post-operative visual acuity were also analyzed. Significant changes were noted in mean logMAR (0.66 to 0.53), foveal thickness (231.1 to 151.1 μm), and IS/OS length (514.9 to 832.3 μm) after the treatment. ELM length did not improve significantly (1,312.4 to 1,376.7 μm). Restoration of IS/OS occurred where ELM is retained. Although pre-operative ELM length, IS/OS length, and foveal thickness showed correlation with p...Continue Reading

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Citations

Dec 6, 2014·Journal of Ophthalmology·Fatimah MohammadMahnaz Shahidi
Dec 18, 2013·Survey of Ophthalmology·Robert P FingerRobyn H Guymer
Aug 27, 2015·Progress in Retinal and Eye Research·Ursula Schmidt-Erfurth, Sebastian M Waldstein
Aug 29, 2014·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Tomoharu NishimuraDaijiro Kurosaka
Jan 27, 2015·Archivos de la Sociedad Española de Oftalmología·A Valverde-MegíasJ García-Feijoo
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Nov 22, 2015·Clinical & Experimental Ophthalmology·Lingwei William TaoChi D Luu
Nov 7, 2016·Archivos de la Sociedad Española de Oftalmología·V Castro-NavarroC Navarro-Palop
Feb 13, 2019·Stem Cells Translational Medicine·Marco ZarbinEllen Townes-Anderson
Aug 2, 2019·Investigative Ophthalmology & Visual Science·Petr SoukupSimon Pot
Feb 27, 2019·Investigative Ophthalmology & Visual Science·Tatsuya YoshitakeAkitaka Tsujikawa
Aug 12, 2020·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Malgorzata WoronkowiczOren Tomkins-Netzer
Feb 21, 2021·Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie·Andrew X ChenKatherine E Talcott
Aug 3, 2021·Journal of Ophthalmology·Cristian MetrangoloClaudio Azzolini
Oct 13, 2020·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde·Verónica Castro-NavarroEnrique Cervera-Taulet

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