PMID: 7367043Apr 1, 1980Paper

Recovery of Schistosoma mansoni from the skin, lungs and hepatic portal system of naive mice and mice previously exposed to S. mansoni: evidence for two phases of parasite attrition in immune mice

Parasitology
S R Smithers, K Gammage

Abstract

New or improved techniques for recovering Schistosoma mansoni from the skin, lungs and liver have enabled us to trace the attrition of a challenge infection in naive (i.e. previously uninfected) and chronically infected mice. Within each experiment, numbers of schistosomes recovered from the skin of naive mice on day 2 after challenge or from the skin and lungs on days 3, 4 or 5, did not differ significantly from the numbers recovered from the liver on days 14, 21, 28 or 35. Approximately 65% of cercariae which penetrated the skin failed to be recovered from naive mice by any of the assays and it appeared that these schistosomes had already died in the skin in the first 24 h. No further significant loss of the infection was detected in naive mice. In chronically infected mice a further attrition of the challenge infection was demonstrated in two distinct phases. An 'early phase' occurred within the first 3 days of exposure and accounted for the death of 30% of the remaining parasites. A 'late phase' occurred between days 6 and 14 and accounted for an additional 43% of deaths. Thus, the two phases of attrition accounted for a loss of approximately 73% of the infection that would have survived in a naive mice. The late phase of a...Continue Reading

References

Nov 1, 1977·The American Journal of Tropical Medicine and Hygiene·S R SmithersF J Ramalho-Pinto
Nov 1, 1977·The American Journal of Tropical Medicine and Hygiene·A E Butterworth
Aug 1, 1979·The Journal of Allergy and Clinical Immunology·A B Kay
Nov 1, 1977·The American Journal of Tropical Medicine and Hygiene·A Sher
Jan 1, 1978·The Journal of Experimental Medicine·F J Ramalho-PintoS R Smithers
Oct 6, 1969·Annals of the New York Academy of Sciences·S R Smithers, R J Terry

Citations

Sep 1, 1989·International Journal for Parasitology·A FlisserD J McLaren
Apr 1, 1993·International Journal for Parasitology·K P Piper, D J McLaren
Jan 1, 1985·Transactions of the Royal Society of Tropical Medicine and Hygiene·A E ButterworthJ H Ouma
Nov 1, 1985·Molecular and Biochemical Parasitology·H J VialA Capron
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Mar 1, 1988·Molecular and Biochemical Parasitology·L D OliginoD A Harn
Mar 7, 2009·Parasitology·R A Wilson
Oct 1, 1983·Parasitology·N A Moloney, G Webbe
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Apr 1, 1995·Molecular and Biochemical Parasitology·M CamachoA Agnew
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Aug 1, 1992·Immunological Investigations·A DesseinA Bourgois
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Related Concepts

Lung
Portal System
Schistosoma
Schistosoma mansoni
Katayama Fever
Skin

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