Recovery of smell sense loss by mepolizumab in a patient allergic to Dermatophagoides and affected by chronic rhinosinusitis with nasal polyps

Clinical and Molecular Allergy : CMA
Carlo CavaliereSimonetta Masieri

Abstract

Chronic rhinosinusitis with nasal polyps (CRSwNP) frequently presents with dysfunction or loss of the sense of smell, resulting in a significant impairment in quality of life. The medical treatments currently available may improve the olfactory function in patients with CRSwNP, but such an outcome is generally only transitory. We report the case of a patient with CRSwNP who completely recovered from smell sense loss by treatment with mepolizumab. The patient was a 62-year-old female who has severe asthma induced by allergy to Dermatophagoides and concomitant CRSwNP. Any treatment for the latter, including oral and injective corticosteroids, was unsuccessful in the loss of smell. Due to the satisfaction of admission criteria to mepolizumab treatment for severe asthma, treatment was initiated on March 2018, resulting in good clinical control of both asthma and CRSwNP, and particularly in complete recovery of the smell loss after 4 months of treatment and still persisting. In this case report, the treatment with mepolizumab in a patient allergic to Dermatophagoides and affected by CRSwNP was associated with an improvement of anosmia. That finding may be explained by a reduction of the nasal obstruction by nasal polyps.

References

Jun 18, 2017·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Frank C AlbersRobert Y Suruki
Jul 9, 2017·The Journal of Allergy and Clinical Immunology·Claus BachertWytske J Fokkens
Sep 19, 2017·The Annals of Otology, Rhinology, and Laryngology·Alexander Rivero, Jonathan Liang
Mar 13, 2018·Rhinology. Supplement·T HummelA Welge-Luessen
Jul 12, 2018·Current Allergy and Asthma Reports·Wirach ChitsuthipakornKornkiat Snidvongs
Jul 22, 2018·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Dawei WuYongxiang Wei

❮ Previous
Next ❯

Citations

Aug 20, 2019·Expert Review of Clinical Immunology·Carlo CavaliereCristoforo Incorvaia
Dec 29, 2020·Laryngoscope Investigative Otolaryngology·Xiaoguang YanThomas Hummel
Apr 13, 2020·Immunology and Allergy Clinics of North America·Omar G Ahmed, Nicholas R Rowan

❮ Previous
Next ❯

Related Concepts

Related Feeds

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Allergies & Environmental Factors

Environmental factors are strongly associated with the prevalence of allergies and are an increasing health concern worldwide. Discover the latest research on Allergies and Environmental Factors here.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Related Papers

Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery
Xiao GuLi Shi
The Cochrane Database of Systematic Reviews
Joanne RimmerClaire Hopkins
© 2022 Meta ULC. All rights reserved