Recovery of splenic infarction with anti-platelet treatments and platelet-apheresis in polycythemia vera

Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis
Irfan YavasogluZahit Bolaman

Abstract

Thrombo-embolic events in coronary and peripheral arteries, and cerebral, pulmonary, portal, hepatic, and deep veins are seen in 27-45% of patients with polycythemia vera (PV). A 79-year-old man was admitted with complaints of pruritus increasing after bath and left upper abdominal pain radiating to left shoulder for two months. On physical examination, ruddy and hyperemic appearances of his face and conjunctiva, tenderness on the left upper quadrant, and splenomegaly were noted. Hemoglobin level was 16.6g/dl, hematocrit 53.8%, white blood cell count 26x10(9)/l, and platelet count 1.032x10(9)/l. Bone marrow aspiration and biopsy revealed hypercellularity, megakaryocytic hyperplasia and dysplasia. The leukocyte alkaline phosphatase score was 190. The levels of serum vitamin B12 and D-dimer were 316 pg/ml and 744 ng/ml, respectively. Arterial O2 saturation was 96%. Red cell mass was measured as 43 ml/kg using radionuclide 51Cr labelled erythrocyte scintigraphy. On cytogenetic analysis, deletion of 20q was found. Computed tomography of whole abdomen showed diffuse splenomegaly and two hypodense areas indicating splenic infarction in 2.5x2 and 3.5x3 cm diameters in subcapsular localization of the spleen. The patient was treated wit...Continue Reading

References

Nov 1, 1994·American Journal of Hematology·S Nand, E Orfei
Jul 1, 1993·AJR. American Journal of Roentgenology·W R Downer, M S Peterson
Jan 1, 1996·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·A SagripantiA Carpi
Feb 29, 2000·Archives of Family Medicine·P P TóthJ MacDonald
Jul 20, 2000·Annals of Hematology·S BrodmannR C Skoda
Mar 14, 2002·American Journal of Hematology·Ali Hassan Al JamaIbrahim Abdalla Al Dabbous
Feb 1, 2003·American Journal of Surgery·John R MeansKurt R Stahlfeld
Feb 14, 2003·Mayo Clinic Proceedings·Ayalew Tefferi
Jun 26, 2004·Pathologie-biologie·Guido Finazzi, UNKNOWN low-dose aspirin in polycythemia (ECLAP)
Oct 2, 2004·International Journal of Cardiology·Gurhan KadikoyluZahit Bolaman

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Citations

Jun 9, 2007·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Irfan YavasogluZahit Bolaman
Jun 23, 2010·Journal of Clinical Apheresis·Zbigniew M SzczepiorkowskiUNKNOWN Apheresis Applications Committee of the American Society for Apheresis

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