PMID: 3745022Jan 1, 1986Paper

Recovery of threshold shift in hair-cell stereocilia following exposure to intense stimulation

Hearing Research
J C Saunders, A Flock

Abstract

The isolated cochlear coil preparation was used to study changes in hair-cell stereocilia stiffness before and after overstimulation. Results were obtained from inner and outer hair cells in the apical and middle turns of the guinea pig cochlea. The stereocilia bundles were stimulated with an oscillating water jet and their movements were identified with stroboscopic illumination in a differential interference contrast microscope. The intensity of the water jet could be varied in decibel steps and the attenuation needed to achieve a 'visual detection level' threshold of movement was the criterion response throughout. Pre-exposure thresholds were sampled, the stereocilia bundle was overstimulated, and thresholds were measured during a recovery interval. Sensory hair bundles on all hair-cell rows showed a loss in stiffness following overstimulation which was proportional to the impedance of the stereocilia bundle. During recovery, stiffness increased and often showed a return to the pre-exposure threshold level. The results demonstrated that the loss of sensory hair stiffness following overstimulation recovered with the passage of time. The magnitude of the initial threshold shift, however, was related to the exposure conditions,...Continue Reading

References

Mar 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·A J Hudspeth, R Jacobs
Jan 1, 1979·Acta Oto-laryngologica·M C Liberman, D G Beil
Nov 1, 1978·The Journal of Physiology·I J Russell, P M Sellick
Feb 1, 1977·The Journal of the Acoustical Society of America·J C SaundersJ D Miller
Jul 1, 1985·The Journal of the Acoustical Society of America·J C SaundersS P Dear
Sep 1, 1985·The Journal of the Acoustical Society of America·J C SaundersM E Schneider
Aug 1, 1983·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·T J Garfinkle, J C Saunders
Jul 1, 1984·Hearing Research·A F Flock, D Strelioff
Jul 1, 1984·Hearing Research·D Strelioff, A Flock
May 1, 1980·The Journal of the Acoustical Society of America·D J Lim
Nov 5, 1982·Science·P DallosA Flock
Jan 1, 1981·Archives of Oto-rhino-laryngology·A Wright
Jan 1, 1961·Zeitschrift für Zellforschung und mikroskopische Anatomie·S IURATO

❮ Previous
Next ❯

Citations

Dec 19, 2012·Pflügers Archiv : European journal of physiology·Stefan JacobAnders Fridberger
Dec 1, 1989·Hearing Research·M GuttenplanJ C Saunders
May 1, 1989·Hearing Research·R B PatuzziB M Johnstone
May 1, 1992·Hearing Research·Y M SzymkoJ C Saunders
Jun 7, 2005·Hearing Research·Eric C BielefeldDonald Henderson
Apr 10, 2003·Hearing Research·Akram Pourbakht, Tatsuya Yamasoba
Jul 12, 2003·Hearing Research·Akram Pourbakht, Tatsuya Yamasoba
Aug 1, 1997·Hearing Research·Y M SzymkoL Hertig
Dec 2, 1998·Hearing Research·R Patuzzi, A Moleirinho
Aug 19, 1999·Hearing Research·W JägerA Flock
Feb 1, 2006·Ear and Hearing·Donald HendersonBo Hua Hu
Sep 15, 2012·Hearing Research·Alfred L Nuttall, Anders Fridberger
Jan 11, 2013·International Journal of Pediatrics·Robert V Harrison

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cajal Bodies & Gems

Cajal bodies or coiled bodies are dense foci of coilin protein. Gemini of Cajal bodies, or gems, are microscopically similar to Cajal bodies. It is believed that Cajal bodies play important roles in RNA processing while gems assist the Cajal bodies. Find the latest research on Cajal bodies and gems here.