PMID: 2502920Jul 1, 1989Paper

Recovery of warfarin from an enteral nutrient formula

American Journal of Hospital Pharmacy
T A KuhnH T Karnes

Abstract

The in vitro recovery of warfarin from an enteral nutrient formula after filtration to remove the protein-bound fractions was determined. This study was conducted in two parts. In part 1, 0.25-, 0.50-, and 1-mL aliquots of warfarin sodium stock solution were added to 150 mL of the enteral nutrient formula Osmolite under physiologic conditions to produce warfarin concentrations of 16.7, 33.3, and 66.7 micrograms/mL. In part 2, a 0.5-mL aliquot of the warfarin sodium stock solution was added to Osmolite 100 mL-distilled water 50 mL, Osmolite 75 mL-distilled water 75 mL, and Osmolite 150 mL. The samples were filtered through a membrane that retained macromolecules while allowing warfarin to pass through, and the warfarin concentration was measured by high-performance liquid chromatography. Assays of protein-free buffered control solutions of warfarin before and after filtration indicated that no significant amount of warfarin was retained in the filtration membrane. Significantly less warfarin was recovered from full-strength Osmolite after filtering than before filtering at all warfarin concentrations tested. Significantly more warfarin was recovered from the Osmolite-distilled water solutions than from the undiluted Osmolite. Th...Continue Reading

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