PMID: 18719387Aug 23, 2008Paper

RecQ family helicases in genome stability: lessons from gene disruption studies in DT40 cells

Cell Cycle
M SekiT Enomoto

Abstract

Cells of all living organisms have evolved complex mechanisms to maintain genome stability. There is increasing evidence that spontaneous genomic instability occurs primarily during DNA replication. RecQ DNA helicases function during DNA replication and are essential for the maintenance of genome stability. In human cells, there exist five RecQ DNA helicases, and mutations of three of these helicases, encoded by the BLM, WRN and RECQL4 genes, give rise to the cancer predisposition disorders, Bloom syndrome (BS), Werner syndrome (WS) and Rothmund-Thomson syndrome (RTS), respectively. Individuals suffering from WS and RTS also show premature aging phenotypes. Although the two remaining helicases, RECQL1 and RECQL5, have not yet been associated with heritable human diseases, a single nucleotide polymorphism of RECQL1 is associated with reduced survival of pancreatic cancer, and RecQl5 knockout mice show a predisposition to cancer. Here, we review the functions of eukaryotic RecQ helicases, focusing primarily on BLM in the maintenance of genome stability through various pathways of nucleic acid metabolism and with special reference to DNA replication.

Citations

Mar 5, 2013·The Journal of Microbiology·Do-Hee ChoiSung-Ho Bae
Sep 18, 2009·The Journal of Biological Chemistry·Christopher CappTao-shih Hsieh
Feb 27, 2010·Journal of Pediatric Hematology/oncology·John A D'Orazio
Feb 2, 2013·Surgical Neurology International·Niv PencovichShlomi Constantini
Nov 5, 2010·Annual Review of Genetics·Kara A BernsteinRodney Rothstein
May 1, 2010·Critical Reviews in Biochemistry and Molecular Biology·Christopher CappTao-Shih Hsieh
Mar 25, 2009·FEBS Letters·Bei ZhouFumiaki Uchiumi
Feb 27, 2013·Chembiochem : a European Journal of Chemical Biology·Balayeshwanth R VummidiNathan W Luedtke
Jan 12, 2010·DNA Repair·Yuliang Wu, Robert M Brosh
Jun 6, 2009·Cell·Kara A Bernstein, Rodney Rothstein
Jul 11, 2009·The Journal of Bone and Joint Surgery. American Volume·Esther de Graaff, Scott H Kozin
Mar 26, 2011·Journal of Biochemistry·Hisao Masai
Aug 3, 2018·Protein & Cell·Lingling GengGuang-Hui Liu
Mar 13, 2019·Annual Review of Biophysics·J Brooks Crickard, Eric C Greene
Mar 10, 2019·Proceedings of the National Academy of Sciences of the United States of America·Chaoyou XueEric C Greene

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